Fucoidan may treat jellyfish dermatitis by inhibiting the inflammatory effect of jellyfish venom
文献类型：期刊论文
| 作者 | Li, Aoyu1,2,3; Yue, Yang3 ; Li, Rongfeng1,3; Yu, Chunlin1,3; Wang, Xueqin1,3; Liu, Song1,3; Xing, Ronge1,3; Li, Pengcheng1,3; Zhang, Quanbin3; Yu, Huahua1,3
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| 刊名 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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| 出版日期 | 2023-12-31 |
| 卷号 | 253页码:13 |
| 关键词 | Fucoidan Jellyfish dermatitis Jellyfish envenomation |
| ISSN号 | 0141-8130 |
| DOI | 10.1016/j.ijbiomac.2023.127449 |
| 通讯作者 | Yu, Huahua(yuhuahua@qdio.ac.cn) |
| 英文摘要 | Jellyfish dermatitis is a common medical problem caused by jellyfish stings. However, there are no targeted and effective medications for their treatment. Here, the biological activity of fucoidan for treatment of jellyfish dermatitis was investigated for the first time. 3 mg/mL Fucoidan attenuated the inflammatory effects of Nemopilema nomurai nematocyst venom (NnNV), including dermal toxicity and myotoxicity. Fucoidan may decrease the inflammatory effects of NnNV by downregulating MAPK and NF-kappa B pathways. This may be attributed to the inhibitory effect of fucoidan on metalloproteinases and phospholipase A2 (PLA2) in NnNV. 3 mg/mL fucoidan reduced the metalloproteinase activity in NnNV from 316.33 +/- 20.84 U/mg to 177.33 +/- 25.36 U/mg, while the inhibition of PLA2 activity in NnNV by 1 mg/mL fucoidan could reach 37.67 +/- 3.42 %. Besides, external application of 3 mg/mL fucoidan can effectively alleviate the symptoms of jellyfish dermatitis. These observations suggest that fucoidan has considerable potential for treatment of jellyfish dermatitis and could be regarded as a novel medicine for jellyfish envenomation. This study provides new ideas for treatment of jellyfish envenomation and suggests evidence for the use of fucoidan in the treatment of jellyfish dermatitis as well as broadens the potential application of fucoidan in clinical practice. |
| WOS关键词 | SULFATED POLYSACCHARIDE ; SCYPHOZOA ; DISCHARGE ; CNIDARIA |
| 资助项目 | National Natural Science Foundation of China[41776163] ; National Natural Science Foundation of China[41876164] ; National Key Research and Development Program of China[2019YFC0312605] ; National Key Research and Development Program of China[2017YFE0111100- 04] ; Natural Science Foundation of Shandong Province[ZR2019QD012] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001102037000001 |
| 出版者 | ELSEVIER |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/183858]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Yu, Huahua |
| 作者单位 | 1.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Drugs & Bioprod, 1 Wenhai Rd, Qingdao 266237, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, 7 Nanhai Rd, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Aoyu,Yue, Yang,Li, Rongfeng,et al. Fucoidan may treat jellyfish dermatitis by inhibiting the inflammatory effect of jellyfish venom[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2023,253:13. |
| APA | Li, Aoyu.,Yue, Yang.,Li, Rongfeng.,Yu, Chunlin.,Wang, Xueqin.,...&Yu, Huahua.(2023).Fucoidan may treat jellyfish dermatitis by inhibiting the inflammatory effect of jellyfish venom.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,253,13. |
| MLA | Li, Aoyu,et al."Fucoidan may treat jellyfish dermatitis by inhibiting the inflammatory effect of jellyfish venom".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 253(2023):13. |
入库方式： OAI收割
来源：海洋研究所
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