Transcriptional regulation analysis reveals the complexity of metamorphosis in the Pacific oyster (Crassostrea gigas)
文献类型：期刊论文
| 作者 | Xu, Fei1,4,5,6; Deng, Shaoxi1,2,3,6 ; Gavriouchkina, Daria7,8; Zhang, Guofan1,4,5,6
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| 刊名 | MARINE LIFE SCIENCE & TECHNOLOGY
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| 出版日期 | 2023-11-25 |
| 页码 | 11 |
| ISSN号 | 2096-6490 |
| 关键词 | Gene regulation network Indirect development Lophotrochozoa Nuclear receptors Neurohormones Protein synthesis Transcription factors |
| DOI | 10.1007/s42995-023-00204-y |
| 通讯作者 | Xu, Fei(xufei@qdio.ac.cn) |
| 英文摘要 | Many marine invertebrate phyla are characterized by indirect development. These animals transit from planktonic larvae to benthic spats via settlement and metamorphosis, which contributes to their adaption to the marine environment. Studying the biological process of metamorphosis is, thus, key to understanding the origin and evolution of indirect development. Although numerous studies have been conducted on the relationship between metamorphosis and the marine environment, microorganisms, and neurohormones, little is known about gene regulation network (GRN) dynamics during metamorphosis. Metamorphosis-competent pediveligers of the Pacific oyster Crassostrea gigas were assayed in this study. By assaying gene expression patterns and open chromatin region changes of different samples of larvae and spats, the dynamics of molecular regulation during metamorphosis were examined. The results indicated significantly different gene regulation networks before, during and post-metamorphosis. Genes encoding membrane-integrated receptors and those related to the remodeling of the nervous system were upregulated before the initiation of metamorphosis. Massive biogenesis, e.g., of various enzymes and structural proteins, occurred during metamorphosis as inferred from the comprehensive upregulation of the protein synthesis system post epinephrine stimulation. Hierarchical downstream gene networks were then stimulated. Some transcription factors, including homeobox, basic helix-loop-helix and nuclear receptors, showed different temporal response patterns, suggesting a complex GRN during the transition stage. Nuclear receptors, as well as their retinoid X receptor partner, may participate in the GRN controlling oyster metamorphosis, indicating an ancient role of the nuclear receptor regulation system in animal metamorphosis. |
| WOS关键词 | BODY PLANS ; GENES ; ORIGINS ; MECHANISMS ; EXPRESSION ; PHYLOGENY ; EVOLUTION ; ARAGONITE ; ALIGNMENT ; MOLLUSKS |
| 资助项目 | Qingdao Frontier Ocean Seed Company Ltd ; Science & Technology Innovation Project of Laoshan Laboratory[LSKJ202203001] ; Key Research and Development Program of Shandong[2022LZGC015] ; Taishan Scholars Program |
| WOS研究方向 | Marine & Freshwater Biology |
| 语种 | 英语 |
| 出版者 | SPRINGERNATURE |
| WOS记录号 | WOS:001107306100001 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/183936]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Xu, Fei |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.City Univ Hong Kong, State Key Lab Marine Pollut, Hong Kong 999077, Peoples R China 3.City Univ Hong Kong, Sch Energy & Environm, Hong Kong 999077, Peoples R China 4.Shandong Technol Innovat Ctr Oyster Seed Ind, Qingdao 266105, Peoples R China 5.Laoshan Lab, Qingdao 266237, Peoples R China 6.Chinese Acad Sci, Qingdao 266071, Peoples R China 7.UCL, UK Dementia Res Inst, London WC1E 6BT, England 8.Okinawa Inst Sci & Technol Grad Univ, Mol Genet Unit, Onna, Okinawa 9040495, Japan |
| 推荐引用方式 GB/T 7714 | Xu, Fei,Deng, Shaoxi,Gavriouchkina, Daria,et al. Transcriptional regulation analysis reveals the complexity of metamorphosis in the Pacific oyster (Crassostrea gigas)[J]. MARINE LIFE SCIENCE & TECHNOLOGY,2023:11. |
| APA | Xu, Fei,Deng, Shaoxi,Gavriouchkina, Daria,&Zhang, Guofan.(2023).Transcriptional regulation analysis reveals the complexity of metamorphosis in the Pacific oyster (Crassostrea gigas).MARINE LIFE SCIENCE & TECHNOLOGY,11. |
| MLA | Xu, Fei,et al."Transcriptional regulation analysis reveals the complexity of metamorphosis in the Pacific oyster (Crassostrea gigas)".MARINE LIFE SCIENCE & TECHNOLOGY (2023):11. |
入库方式： OAI收割
来源：海洋研究所
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