Preparation of Multifunctional Seaweed Polysaccharides Derivatives Composite Hydrogel to Protect Ultraviolet B-Induced Photoaging In Vitro and In Vivo
文献类型：期刊论文
| 作者 | Wu, Yumeng1; Geng, Lihua1,3; Zhang, Jingjing1,2; Wu, Ning1,3; Yang, Yue1,3; Zhang, Quanbin1,3; Duan, Delin1,3; Wang, Jing1,3
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| 刊名 | MACROMOLECULAR BIOSCIENCE
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| 出版日期 | 2023-12-03 |
| 页码 | 16 |
| ISSN号 | 1616-5187 |
| 关键词 | alginate oligosaccharides multifunctional composite hydrogel photoaging sulfated galactofucan polysaccharides ultraviolet B |
| DOI | 10.1002/mabi.202300292 |
| 通讯作者 | Wang, Jing(jingwang@qdio.ac.cn) |
| 英文摘要 | Seaweed polysaccharides can be used for protective skin photoaging which is caused by long-term exposure to ultraviolet B (UVB). In this study, a multifunctional composite hydrogel (FACP5) is prepared using sulfated galactofucan polysaccharides, alginate oligosaccharides as active ingredients, and polyacrylonitrile modified kappa-Carrageenan as substrate. The properties of FACP5 show that it has good water retention, spreadability, and adhesion. The antiphotoaging activity is evaluated in vitro and in vivo. In vitro experiments demonstrate that the components of FACP5 exhibit good biocompatibility, antioxidant, and anti-tyrosinase activities, and could reduce the cell death rate induced by UVB. In vivo experiments demonstrate that, compared with the mice skin in model group, the skin water content treated with FACP5 increases by 29.80%; the thicknesses of epidermis and dermis decrease by 53.56% and 43.98%, respectively; the activities of catalase and superoxide dismutase increase by 1.59 and 0.72 times, respectively; the contents of interleukin-6 and tumor necrosis factor-alpha decrease by 19.21% and 17.85%, respectively; hydroxyproline content increases by 32.42%; the expression level of matrix metalloproteinase-3 downregulates by 42.80%. These results indicate that FACP5 has skin barrier repairing, antioxidant, anti-inflammatory, and inhibiting collagen degradation activies, FACP5 can be used as a skin protection remedy for photoaging. Composite hydrogel (FACP5) is prepared by seaweed polysaccharides. FACP5 components exhibit good biocompatibility, antioxidant, and anti-tyrosinase activities, and reduce the cell death rate induced by ultraviolet B. FACP5 is characterized by viscosity, spreadability, and porous structure. In photodamaged skin, it plays a role in repairing the barrier, reducing the level of oxidative stress and inflammation, and inhibiting collagen degradation.image |
| WOS关键词 | SARGASSUM-FUSIFORME ; SKIN ; MECHANISMS ; INHIBITOR ; RADIATION ; FUCOIDAN |
| 资助项目 | Asia Collaboration Project on Development of Ecological Marine Ranching ; Shandong Provincial Natural Science Foundation[ZR2022MD007] ; Science and Technology project of Fujian Province[2022T3024] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Materials Science ; Polymer Science |
| 语种 | 英语 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| WOS记录号 | WOS:001113469400001 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/184128]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Wang, Jing |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, 7 Nanhai Rd, Qingdao 266071, Peoples R China 2.Qingdao Eighth Peoples Hosp, Dept Pharm, 84 Fengshan Rd, Qingdao 266121, Peoples R China 3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, 168 Wenhai Rd, Qingdao 266237, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Yumeng,Geng, Lihua,Zhang, Jingjing,et al. Preparation of Multifunctional Seaweed Polysaccharides Derivatives Composite Hydrogel to Protect Ultraviolet B-Induced Photoaging In Vitro and In Vivo[J]. MACROMOLECULAR BIOSCIENCE,2023:16. |
| APA | Wu, Yumeng.,Geng, Lihua.,Zhang, Jingjing.,Wu, Ning.,Yang, Yue.,...&Wang, Jing.(2023).Preparation of Multifunctional Seaweed Polysaccharides Derivatives Composite Hydrogel to Protect Ultraviolet B-Induced Photoaging In Vitro and In Vivo.MACROMOLECULAR BIOSCIENCE,16. |
| MLA | Wu, Yumeng,et al."Preparation of Multifunctional Seaweed Polysaccharides Derivatives Composite Hydrogel to Protect Ultraviolet B-Induced Photoaging In Vitro and In Vivo".MACROMOLECULAR BIOSCIENCE (2023):16. |
入库方式： OAI收割
来源：海洋研究所
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