Effects of toxin metalloproteinases from jellyfish Nemopilema nomurai nematocyst on the dermal toxicity and potential treatment of jellyfish dermatitis
文献类型：期刊论文
| 作者 | Li, Aoyu1,2,3; Yu, Huahua2,3 ; Li, Rongfeng2,3; Yue, Yang2; Yu, Chunlin2,3; Liu, Song2,3; Xing, Ronge2,3; Li, Pengcheng2,3
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| 刊名 | INTERNATIONAL IMMUNOPHARMACOLOGY
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| 出版日期 | 2024-02-15 |
| 卷号 | 128页码:12 |
| ISSN号 | 1567-5769 |
| 关键词 | Inflammation Jellyfish dermatitis Jellyfish envenomation Nemopilema nomurai nematocyst venom (NnNV) Metalloproteinase |
| DOI | 10.1016/j.intimp.2024.111492 |
| 通讯作者 | Yu, Huahua(yuhuahua@qdio.ac.cn) |
| 英文摘要 | Jellyfish dermatitis is a common medical problem in many countries due to the jellyfish envenomation. However, there are no specific and targeted medications for their treatment. Here we investigated the possible therapeutic effects of metalloproteinase inhibitors on the dermal toxicity of Nemopilema nomurai nematocyst venom (NnNV), a giant venomous jellyfish from China, using the jellyfish dermatitis model, focusing on inflammatory effector molecules during jellyfish envenomation. Metalloproteinase may further stimulate inflammation by promoting oxidative stress in the organism and play key roles by activating MAPK and NF-kappa B, in the pathogenesis of jellyfish dermatitis. And the metalloproteinase inhibitors batimastat and EDTA disodium salt may treat the Jellyfish dermatitis by inhibiting the metalloproteinase activity in NnNV. These observations suggest that the metalloproteinase components of NnNV make a considerable contribution to dermal toxicity as the inflammation effect molecular, and metalloproteinase inhibitors can be regarded as novel therapeutic medicines in jellyfish envenomation. This study contributes to understanding the mechanism of jellyfish dermatitis and suggests new targets and ideas for the treatment of jellyfish envenomation. |
| WOS关键词 | RHOPILEMA-ESCULENTUM ; OXIDATIVE STRESS ; VENOM ; STINGS ; MANAGEMENT ; INHIBITOR ; DISCHARGE ; CNIDARIA ; BLOOMS |
| 资助项目 | National Key R&D Program of China[41776163] ; National Key R&D Program of China[41876164] ; Natural Sci-ence Foundation of Shandong Province[2019YFC0312605] ; Natural Sci-ence Foundation of Shandong Province[2017YFE0111100-04] ; [ZR2019QD012] |
| WOS研究方向 | Immunology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | ELSEVIER |
| WOS记录号 | WOS:001165303400001 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/184562]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Yu, Huahua |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 3.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Drugs & Bioprod, 1 Wenhai Rd, Qingdao 266237, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Aoyu,Yu, Huahua,Li, Rongfeng,et al. Effects of toxin metalloproteinases from jellyfish Nemopilema nomurai nematocyst on the dermal toxicity and potential treatment of jellyfish dermatitis[J]. INTERNATIONAL IMMUNOPHARMACOLOGY,2024,128:12. |
| APA | Li, Aoyu.,Yu, Huahua.,Li, Rongfeng.,Yue, Yang.,Yu, Chunlin.,...&Li, Pengcheng.(2024).Effects of toxin metalloproteinases from jellyfish Nemopilema nomurai nematocyst on the dermal toxicity and potential treatment of jellyfish dermatitis.INTERNATIONAL IMMUNOPHARMACOLOGY,128,12. |
| MLA | Li, Aoyu,et al."Effects of toxin metalloproteinases from jellyfish Nemopilema nomurai nematocyst on the dermal toxicity and potential treatment of jellyfish dermatitis".INTERNATIONAL IMMUNOPHARMACOLOGY 128(2024):12. |
入库方式： OAI收割
来源：海洋研究所
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