Metabolomic insights into neurological effects of BDE-47 exposure in the sea cucumber Apostichopus japonicus
文献类型：期刊论文
| 作者 | Ding, Kui1,2,3 ; Xu, Qinzeng1,3; Zhang, Xuelei1,3; Liu, Shilin2
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| 刊名 | ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
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| 出版日期 | 2023-11-01 |
| 卷号 | 266页码:11 |
| ISSN号 | 0147-6513 |
| 关键词 | Apostichopus japonicus BDE-47 Nervous system UPLC-Triple-TOF-MS Metabolite Neurotoxicity |
| DOI | 10.1016/j.ecoenv.2023.115558 |
| 通讯作者 | Ding, Kui(dingkui@fio.org.cn) |
| 英文摘要 | The persistent organic pollutant 2,2 ',4,4 '-Tetrabromodiphenyl ether (BDE-47), a prevalent congener among polybrominated diphenyl ethers (PBDEs), exhibits potent bioaccumulation and toxicity. Despite extensive research into the adverse effects of BDE-47, its neurotoxicity in sea cucumbers remains unexplored. Given the crucial role of the sea cucumber's nervous system in survival and adaptation, evaluating the impacts of BDE-47 is vital for sustainable aquaculture and consumption. In this study, we employed ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Triple-TOF-MS) to analyze metabolomic changes in neuro-related tissues of Apostichopus japonicus exposed to low (0.1 mu g/L), medium (1.0 mu g/L), and high (10.0 mu g/L) BDE-47 concentrations. We identified significantly changed metabolites in each exposure group (87 in low, 79 in medium, and 102 in high), affecting a variety of physiological processes such as steroid hormone balance, nucleotide metabolism, energy metabolism, neurotransmitter levels, and neuroprotection. In addition, we identified concentration-dependent, common, and some other metabolic responses in the neuro-related tissues. Our findings reveal critical insights into the neurotoxic effects of BDE-47 in sea cucumbers and contribute to risk assessment related to BDE-47 exposure in the sea cucumber industry, paving the way for future neurotoxicological research in invertebrates. |
| WOS关键词 | POLYBROMINATED DIPHENYL ETHERS ; BROMINATED FLAME RETARDANTS ; OXIDATIVE STRESS ; CALCIUM HOMEOSTASIS ; NEONATAL EXPOSURE ; ACID-METABOLISM ; SERINE RACEMASE ; IMMUNE FUNCTION ; VITAMIN-A ; BEHAVIOR |
| 资助项目 | National Natural Science Founda-tion of China[42106131] |
| WOS研究方向 | Environmental Sciences & Ecology ; Toxicology |
| 语种 | 英语 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| WOS记录号 | WOS:001095010000001 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/183843]  |
| 专题 | 海洋研究所_海洋生态与环境科学重点实验室 |
| 通讯作者 | Ding, Kui |
| 作者单位 | 1.Minist Nat Resources, Inst Oceanog 1, Key Lab Marine Ecoenvironm Sci & Technol, Qingdao 266061, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China 3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Ecol & Environm Sci, Qingdao 266061, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ding, Kui,Xu, Qinzeng,Zhang, Xuelei,et al. Metabolomic insights into neurological effects of BDE-47 exposure in the sea cucumber Apostichopus japonicus[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2023,266:11. |
| APA | Ding, Kui,Xu, Qinzeng,Zhang, Xuelei,&Liu, Shilin.(2023).Metabolomic insights into neurological effects of BDE-47 exposure in the sea cucumber Apostichopus japonicus.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,266,11. |
| MLA | Ding, Kui,et al."Metabolomic insights into neurological effects of BDE-47 exposure in the sea cucumber Apostichopus japonicus".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 266(2023):11. |
入库方式： OAI收割
来源：海洋研究所
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