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ROS-induced moderate autophagy of haemocytes confers resistance of Mercenaria mercenaria to air exposure stress

文献类型：期刊论文

作者Zhou, Cong1,3,4,5,6,7; Zou, Yan8; Hu, Zhi1,3,4,5,6,7; Yang, Mei-jie1,3,5,6,7; Shi, Pu1,3,4,5,6,7; Li, Yong-ren9; Guo, Yong-jun9; Zhang, Tao1,2,3,5,6,7; Song, Hao1,2,3,5,6,7
刊名FISH & SHELLFISH IMMUNOLOGY
出版日期2023-10-01
卷号141页码:11
ISSN号1050-4648
关键词Air exposure Resistance Haemocytes Oxidative stress Autophagy
DOI10.1016/j.fsi.2023.109084
通讯作者Zhang, Tao(tzhang@qdio.ac.cn) ; Song, Hao(haosong@qdio.ac.cn)
英文摘要Air exposure (AE) is a significant environmental stressor that can lead to desiccation, hypoxia, starvation, and disruption of cellular homeostasis in marine bivalves. Autophagy is a highly conserved catabolic pathway that facilitates the degradation of damaged macromolecules and organelles, thereby supporting cellular stress responses. To date, autophagy-mediated resistance mechanisms to AE stress remain largely elusive in bivalves. In this study, we performed a multi-tool approach to investigate the autophagy-related physiological regulation in hard clams (Mercenaria mercenaria) under different duration of AE (T = 0, 1, 5, 10, 20, 30 days). We observed that autophagy of haemocytes was significantly activated on day 5. However, autophagy activity began to significantly decline from day 10 to day 30. Autophagy was significantly inhibited after antioxidant treatment, indicating that reactive oxygen species (ROS) was an endogenous inducer of autophagy. A significant decline in the survival rate of hard clams was observed after injection of ammonium chloride or carbamazepine during AE stress, suggesting that moderate autophagy was conducive for clam survival under AE stress. We also observed DNA breaks and high levels of apoptosis in haemocytes on day 10. Activation of apoptosis lagged behind autophagy, and the relationship between autophagy and apoptosis might shift from antagonism to synergy with the duration of stress. This study provides novel insights into the stress resistance mechanisms in marine bivalves.
WOS关键词OXIDATIVE STRESS ; MYTILUS-GALLOPROVINCIALIS ; LYSOSOMAL REACTIONS ; CELL-DEATH ; APOPTOSIS ; RESPONSES ; IDENTIFICATION ; TEMPERATURE ; MECHANISMS ; PARAMETERS
资助项目Creative Team Project of the Laboratory for Marine Ecology and Environmental Science, Qingdao Pilot National Laboratory for Marine Science and Technology[2021AB34014] ; Young Elite Scientists Sponsorship Program by CAST[LMEES-CTSP-2018-1] ; Youth Innovation Promotion Association CAS[2021QNRC001]
WOS研究方向Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
语种英语
出版者ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
WOS记录号WOS:001101017000001
源URL[http://ir.qdio.ac.cn/handle/337002/183894]  
专题海洋研究所_海洋生态与环境科学重点实验室
通讯作者Zhang, Tao; Song, Hao
作者单位1.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China
2.7 Nanhai Rd, Qingdao City, Shandong, Peoples R China
3.Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
5.Chinese Acad Sci, Inst Oceanol, CAS Engn Lab Marine Ranching, Qingdao 266071, Peoples R China
6.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China
7.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Ecol & Environm Sci, Qingdao 266237, Peoples R China
8.Marine Sci Res Inst Shandong Prov, Qingdao 266100, Peoples R China
9.Tianjin Agr Univ, Fisheries Coll, Tianjin Key Lab Aquaecol & Aquaculture, Tianjin 300384, Peoples R China
推荐引用方式
GB/T 7714		 Zhou, Cong,Zou, Yan,Hu, Zhi,et al. ROS-induced moderate autophagy of haemocytes confers resistance of Mercenaria mercenaria to air exposure stress[J]. FISH & SHELLFISH IMMUNOLOGY,2023,141:11.
APA Zhou, Cong.,Zou, Yan.,Hu, Zhi.,Yang, Mei-jie.,Shi, Pu.,...&Song, Hao.(2023).ROS-induced moderate autophagy of haemocytes confers resistance of Mercenaria mercenaria to air exposure stress.FISH & SHELLFISH IMMUNOLOGY,141,11.
MLA Zhou, Cong,et al."ROS-induced moderate autophagy of haemocytes confers resistance of Mercenaria mercenaria to air exposure stress".FISH & SHELLFISH IMMUNOLOGY 141(2023):11.

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来源：海洋研究所

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