Novel porphyrin derivative containing cations as new photodynamic antimicrobial agent with high efficiency
文献类型：期刊论文
| 作者 | Zhang, Jiajing2,3,4; Yuan, Xiaoqian2; Li, Hongsen2; Yu, Liting2; Zhang, Yulong2; Pang, Keyi2; Sun, Chaoyue2; Liu, Zhongyang2; Li, Jie2 ; Ma, Liying2
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| 刊名 | RSC ADVANCES
 |
| 出版日期 | 2024-01-17 |
| 卷号 | 14期号:5页码:3122-3134 |
| DOI | 10.1039/d3ra07743h |
| 通讯作者 | Ma, Liying() ; Chen, Lingxin(lxchen@yic.ac.cn) |
| 英文摘要 | Bacterial infections from chronic wounds affect about 175 million people each year and are a significant clinical problem. Through the integration of photodynamic therapy (PDT) and chemotherapy, a new photosensitizer consisting of ammonium salt N,N-bis-(2-hydroxyethyl)-N-(6-(4-(10,15,20-trimesitylporphyrin-5-yl) phenoxy) hexane)-N-methanaminium bromide, TMP(+) was successfully synthesized with a total reaction yield of 10%. The novel photosensitizer consists of two parts, a porphyrin photosensitizer part and a quaternary ammonium salt part, to achieve the synergistic effect of photodynamic and chemical antibacterial activity. With the increase of TMP(+) concentration, the diameter of the PCT fiber membranes (POL/COL/TMP(+); POL, polycaprolactone; COL, collagen) gradually increased, which was caused by the charge of the quaternary ammonium salt. At the same time, the antibacterial properties were gradually improved. We finally selected the PCT 0.5% group for the antibacterial experiment, with excellent performance in fiber uniformity, hydrophobicity and biosafety. The antibacterial experiment showed that the modified porphyrin TMP(+) had a better antibacterial effect than others. In vivo chronic wound healing experiments proved that the antibacterial and anti-inflammatory effect of the PCTL group was the best, further confirmed by H&E histological analysis, immunofluorescence and immunohistochemistry mechanism experiments. This research lays the foundation for the manufacture of novel molecules that combine chemical and photodynamic strategies. A new photosensitizer consisting of ammonium salt, TMP(+) was synthesized and achieved the synergistic effect of photodynamic and chemical antibacterial activity. Experiments showed promising bactericidal properties, while accelerating the healing of Staphylococcus aureus infected mice. |
| 资助项目 | National Natural Science Foundation of China[22001020] ; Foundation of Binzhou Medical University[2019KYQD23] ; Foundation of Binzhou Medical University[2022KYQD27] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001144849200001 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/184272]  |
| 专题 | 海洋研究所_海洋生态与环境科学重点实验室 |
| 通讯作者 | Ma, Liying; Chen, Lingxin |
| 作者单位 | 1.Pilot Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China 2.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China 3.Chinese Acad Sci, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 4.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Jiajing,Yuan, Xiaoqian,Li, Hongsen,et al. Novel porphyrin derivative containing cations as new photodynamic antimicrobial agent with high efficiency[J]. RSC ADVANCES,2024,14(5):3122-3134. |
| APA | Zhang, Jiajing.,Yuan, Xiaoqian.,Li, Hongsen.,Yu, Liting.,Zhang, Yulong.,...&Chen, Lingxin.(2024).Novel porphyrin derivative containing cations as new photodynamic antimicrobial agent with high efficiency.RSC ADVANCES,14(5),3122-3134. |
| MLA | Zhang, Jiajing,et al."Novel porphyrin derivative containing cations as new photodynamic antimicrobial agent with high efficiency".RSC ADVANCES 14.5(2024):3122-3134. |
入库方式： OAI收割
来源：海洋研究所
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