Dual-signal viscosity flow paper sensor for ATP detection based on bio-recognition and nanozyme activity regulation of ZIF-90
文献类型：期刊论文
| 作者 | Wang, Yingwen2,3; Qi, Peng1,2 ; Zhang, Dun1,2; Zeng, Yan1,2; Sun, Yan1,2; Wang, Peng1,2
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| 刊名 | CHEMICAL ENGINEERING JOURNAL
 |
| 出版日期 | 2024-02-01 |
| 卷号 | 481页码:9 |
| ISSN号 | 1385-8947 |
| 关键词 | Paper-based ATP assay Degradation of high viscosity hydrogel Nanozyme reactivation Onsite detection ZIF-90 |
| DOI | 10.1016/j.cej.2024.148590 |
| 通讯作者 | Qi, Peng(qipeng@qdio.ac.cn) ; Zhang, Dun(zhangdun@qdio.ac.cn) ; Wang, Peng(wangpeng@qdio.ac.cn) |
| 英文摘要 | Adenosine triphosphate (ATP) is an important biological biomarker, but its rapid extracellular decomposition poses challenges for on-site detection. We report a paper-based dual-readout viscosity flow sensor enabling rapid, equipment-free quantification of ATP. The assay integrates molybdenum disulfide nanozymes for signal amplification with zeolitic imidazolate framework-90 (ZIF-90) for selective ATP recognition and nanozyme regulation. In the presence of ATP, the intact chitosanase-encapsulated ZIF-90 structure was disintegrated to release chitosanase and thus hydrolyzed chitosan hydrogel, decreasing the viscosity of chitosan solution. Moreover, elimination of ZIF-90 inhibitory effect reactivated the catalytic activity of MoS2 nanozyme, resulting in the oxidation of 3,3 ',5,5 '-tetramethylbenzidine (TMB) to produce obvious color change. The analytical signals, combining the distance- and colorimetric- readout, were directly displayed on filter paper without further processed. The proposed dual-readout viscosity flow sensor exhibited remarkable sensitivity for ATP detection with detection limits down to 0.038 nM with the distance-readout and 0.057 nM for the colorimetric-readout. Furthermore, we developed an integrated paper kit with a printed scale and color card for standardized on-site analysis without instrumentation. Successful application for ATP quantification in bacterial biofilms and blood samples demonstrates the sensor's strong performance and potential for decentralized testing. |
| WOS关键词 | PATHOGENS ; ANTIBODY ; ACID |
| 资助项目 | National Natural Science Foundation of China[42376208] |
| WOS研究方向 | Engineering |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCIENCE SA |
| WOS记录号 | WOS:001161457900001 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/184441]  |
| 专题 | 海洋研究所_海洋腐蚀与防护研究发展中心 |
| 通讯作者 | Qi, Peng; Zhang, Dun; Wang, Peng |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100039, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Key Lab Marine Environm Corros & Biofouling, Qingdao 266071, Peoples R China 3.Chinese Acad Agr Sci, Key Lab Tobacco Pest Monitoring & Integrated Manag, Tobacco Res Inst, Qingdao 266101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Yingwen,Qi, Peng,Zhang, Dun,et al. Dual-signal viscosity flow paper sensor for ATP detection based on bio-recognition and nanozyme activity regulation of ZIF-90[J]. CHEMICAL ENGINEERING JOURNAL,2024,481:9. |
| APA | Wang, Yingwen,Qi, Peng,Zhang, Dun,Zeng, Yan,Sun, Yan,&Wang, Peng.(2024).Dual-signal viscosity flow paper sensor for ATP detection based on bio-recognition and nanozyme activity regulation of ZIF-90.CHEMICAL ENGINEERING JOURNAL,481,9. |
| MLA | Wang, Yingwen,et al."Dual-signal viscosity flow paper sensor for ATP detection based on bio-recognition and nanozyme activity regulation of ZIF-90".CHEMICAL ENGINEERING JOURNAL 481(2024):9. |
入库方式： OAI收割
来源：海洋研究所
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