A proteomic landscape of pharmacologic perturbations for functional relevance
文献类型：期刊论文
| 作者 | Liu, Zhiwei4; Jiang, Shangwen4; Hao, Bingbing4; Xie, Shuyu3; Liu, Yingluo4; Huang, Yuqi4; Xu, Heng4; Luo, Cheng3,4 ; Huang, Min4; Tan, Minjia1,2,3,4
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| 刊名 | JOURNAL OF PHARMACEUTICAL ANALYSIS
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| 出版日期 | 2024 |
| 卷号 | 14期号:1页码:128-139 |
| ISSN号 | 2095-1779 |
| 关键词 | Proteomics Drug Perturbation Drug target Drug combination |
| DOI | 10.1016/j.jpha.2023.08.021 |
| 通讯作者 | Xu, Jun-Yu(jyxu@simm.ac.cn) |
| 英文摘要 | Pharmacological perturbation studies based on protein-level signatures are fundamental for drug discovery. In the present study, we used a mass spectrometry (MS)-based proteomic platform to profile the whole proteome of the breast cancer MCF7 cell line under stress induced by 78 bioactive compounds. The integrated analysis of perturbed signal abundance revealed the connectivity between phenotypic behaviors and molecular features in cancer cells. Our data showed functional relevance in exploring the novel pharmacological activity of phenolic xanthohumol, as well as the noncanonical targets of clinically approved tamoxifen, lovastatin, and their derivatives. Furthermore, the rational design of synergistic inhibition using a combination of histone methyltransferase and topoisomerase was identified based on their complementary drug fingerprints. This study provides rich resources for the proteomic landscape of drug responses for precision therapeutic medicine. (c) 2023 The Authors. Published by Elsevier B.V. on behalf of Xi'an Jiaotong University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| WOS关键词 | MICROBIAL NATURAL-PRODUCTS ; DRUG-RESISTANCE ; LARGE-SCALE ; CANCER ; POLYPHARMACOLOGY ; PROTEINS ; CELLS ; GENERATION ; INHIBITORS ; SIGNATURES |
| 资助项目 | Natural Science Foundation of China[22225702] ; Natural Science Foundation of China[32322048] ; National Key R &D Program of China[2020YFE0202200] ; Shanghai Academic/Technology Research Leader Program, China[22XD1420900] ; Guangdong High-level New R &D Institute, China ; Guangdong High-level Innovative Research Institute, China ; Shanghai Rising -Star Program, China[2022QNRC001] ; Youth Innovation Promotion Association of the Chinese Academy of Sciences[KF-202201] ; Young Elite Scientists Sponsorship Program by China Association for Science and Technology, China[SHSMU-ZDCX2021270 0] ; Open Fund of State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, China[2019B090904008] ; Innovative Research Team of High -Level Local Universities in Shanghai, China[2021B0909050003] ; Sanofi scholarship program ; [22QA1411100] ; [2021276] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | ELSEVIER |
| WOS记录号 | WOS:001170623000001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309895]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Xu, Jun-Yu |
| 作者单位 | 1.Nanjing Univ, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Peoples R China 2.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Guangdong, Peoples R China 3.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Zhiwei,Jiang, Shangwen,Hao, Bingbing,et al. A proteomic landscape of pharmacologic perturbations for functional relevance[J]. JOURNAL OF PHARMACEUTICAL ANALYSIS,2024,14(1):128-139. |
| APA | Liu, Zhiwei.,Jiang, Shangwen.,Hao, Bingbing.,Xie, Shuyu.,Liu, Yingluo.,...&Xu, Jun-Yu.(2024).A proteomic landscape of pharmacologic perturbations for functional relevance.JOURNAL OF PHARMACEUTICAL ANALYSIS,14(1),128-139. |
| MLA | Liu, Zhiwei,et al."A proteomic landscape of pharmacologic perturbations for functional relevance".JOURNAL OF PHARMACEUTICAL ANALYSIS 14.1(2024):128-139. |
入库方式： OAI收割
来源：上海药物研究所
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