Immunotherapy Innovations in the Fight against Osteosarcoma: Emerging Strategies and Promising Progress
文献类型：期刊论文
| 作者 | Cheng, Shigao3,4; Wang, Huiyuan2 ; Kang, Xuejia1; Zhang, Hui4
|
| 刊名 | PHARMACEUTICS
 |
| 出版日期 | 2024-02-01 |
| 卷号 | 16期号:2页码:21 |
| 关键词 | osteosarcoma suppressive immune environment nanoparticles immunotherapy |
| DOI | 10.3390/pharmaceutics16020251 |
| 通讯作者 | Zhang, Hui(footanklecenterwch@163.com) |
| 英文摘要 | Immunosuppressive elements within the tumor microenvironment are the primary drivers of tumorigenesis and malignant advancement. The presence, as well as the crosstalk between myeloid-derived suppressor cells (MDSCs), osteosarcoma-associated macrophages (OS-Ms), regulatory T cells (Tregs), and endothelial cells (ECs) with osteosarcoma cells cause the poor prognosis of OS. In addition, the consequent immunosuppressive factors favor the loss of treatment potential. Nanoparticles offer a means to dynamically and locally manipulate immuno-nanoparticles, which present a promising strategy for transforming OS-TME. Additionally, chimeric antigen receptor (CAR) technology is effective in combating OS. This review summarizes the essential mechanisms of immunosuppressive cells in the OS-TME and the current immune-associated strategies. The last part highlights the limitations of existing therapies and offers insights into future research directions. |
| WOS关键词 | REGULATORY T-CELLS ; QUALITY-OF-LIFE ; TUMOR PROGRESSION ; PD-L1 EXPRESSION ; MACROPHAGE INFILTRATION ; PHOTODYNAMIC THERAPY ; CANCER-IMMUNOTHERAPY ; IN-VITRO ; NANOPARTICLES ; MECHANISMS |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | MDPI |
| WOS记录号 | WOS:001172208600001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309934]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhang, Hui |
| 作者单位 | 1.Auburn Univ, Harrison Coll Pharm, Dept Drug Discovery & Dev, Auburn, AL 36849 USA 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China 3.Hunan Loudi Cent Hosp, Dept Orthoped, Loudi 417000, Peoples R China 4.Sichuan Univ, West China Hosp, Lab Stem Cell & Tissue Engn, Orthoped Res Inst,Dept Orthoped, Chengdu 610041, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cheng, Shigao,Wang, Huiyuan,Kang, Xuejia,et al. Immunotherapy Innovations in the Fight against Osteosarcoma: Emerging Strategies and Promising Progress[J]. PHARMACEUTICS,2024,16(2):21. |
| APA | Cheng, Shigao,Wang, Huiyuan,Kang, Xuejia,&Zhang, Hui.(2024).Immunotherapy Innovations in the Fight against Osteosarcoma: Emerging Strategies and Promising Progress.PHARMACEUTICS,16(2),21. |
| MLA | Cheng, Shigao,et al."Immunotherapy Innovations in the Fight against Osteosarcoma: Emerging Strategies and Promising Progress".PHARMACEUTICS 16.2(2024):21. |
入库方式： OAI收割
来源：上海药物研究所
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