Selenadiazolesbenzothiadiazole-Based Small Donor-Acceptor-Donor Dye for Photothermal Therapy in NIR-II Window
文献类型：期刊论文
| 作者 | Wu, Yibin3; Ji, Aiyan2; Lou, Hongyue2; Song, Ruihu2; Cheng, Zhen1,2; Chen, Wen-hua3; Qu, Chunrong2 |
| 刊名 | ADVANCED THERAPEUTICS
 |
| 出版日期 | 2023-07-19 |
| 关键词 | near-infrared-II fluorescence imaging organic dye photothermal therapy small molecule |
| DOI | 10.1002/adtp.202300159 |
| 文献子类 | Article |
| 英文摘要 | Recently, photothermal therapy (PTT) has attracted enormous attention because of its low invasiveness, high spatiotemporal selectivity, and good therapeutic effect. Different types of photothermal conversion agents have been developed, particularly the second near-infrared window (NIR-II, 1000-1700 nm) organic small molecular dyes which have become an attractive research direction. Herein, a novel and simple donor-acceptor-donor (D-A-D) type NIR-II dye SeC is designed and synthesized with 2 & lambda;4 & delta;2-[1,2,5]selenadiazolo[3,4-f]-2,1,3-benzothiadiazole structure. To improve capability of SeC for biomedical applications, SeC molecules are encapsulated into DSPE-PEG(2000) to construct nanoparticles SeC-NPs, which show high photostability and biocompatibility. More importantly, SeC-NPs exhibited an excellent photothermal performance and display high photothermal conversion efficiency (PCE) of 62% under 808 nm excitation. Because of favorable fluorescence property in NIR-II window and high PCE, SeC-NPs are successfully used for NIR-II imaging and PTT of 4T1 tumor-bearing mice models. In vivo studies demonstrate SeC-NPs' ability to suppress tumor growth under NIR photoirradiation without visible damage to main organs. Overall, this study develops a strategy to design a simple small molecule dye containing selenium for NIR-II imaging, and SeC-NPs shows high performance for PTT toward tumor. |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001027958600001 |
| 出版者 | WILEY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309637]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Cheng, Zhen; Chen, Wen-hua; Qu, Chunrong |
| 作者单位 | 1.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Materia Med, Mol Imaging Ctr, State Key Lab Drug Res, Shanghai, Peoples R China; 3.Wuyi Univ, Sch Biotechnol & Hlth Sci, Jiangmen 529020, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Wu, Yibin,Ji, Aiyan,Lou, Hongyue,et al. Selenadiazolesbenzothiadiazole-Based Small Donor-Acceptor-Donor Dye for Photothermal Therapy in NIR-II Window[J]. ADVANCED THERAPEUTICS,2023. |
| APA | Wu, Yibin.,Ji, Aiyan.,Lou, Hongyue.,Song, Ruihu.,Cheng, Zhen.,...&Qu, Chunrong.(2023).Selenadiazolesbenzothiadiazole-Based Small Donor-Acceptor-Donor Dye for Photothermal Therapy in NIR-II Window.ADVANCED THERAPEUTICS. |
| MLA | Wu, Yibin,et al."Selenadiazolesbenzothiadiazole-Based Small Donor-Acceptor-Donor Dye for Photothermal Therapy in NIR-II Window".ADVANCED THERAPEUTICS (2023). |
入库方式： OAI收割
来源：上海药物研究所
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