GPR84 regulates pulmonary inflammation by modulating neutrophil functions
文献类型：期刊论文
| 作者 | Wang, Si-wei5,6; Zhang, Qing3,4,6 ; Lu, Dan2; Fang, You-chen6; Yan, Xiao-ci4,5,6; Chen, Jing5,6; Xia, Zhi-kan5,6; Yuan, Qian-ting6; Chen, Lin-hai6; Zhang, Yang-ming1
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| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2023-08-01 |
| 卷号 | 44期号:8页码:1665-1675 |
| 关键词 | GPR84 acute lung injury inflammation neutrophil ROS antagonist |
| DOI | 10.1038/s41401-023-01080-z |
| 文献子类 | Article |
| 英文摘要 | Acute lung injury (ALI) is an acute, progressive hypoxic respiratory failure that could develop into acute respiratory distress syndrome (ARDS) with very high mortality rate. ALI is believed to be caused by uncontrolled inflammation, and multiple types of immune cells, especially neutrophils, are critically involved in the development of ALI. The treatment for ALI/ARDS is very limited, a better understanding of the pathogenesis and new therapies are urgently needed. Here we discover that GPR84, a medium chain fatty acid receptor, plays critical roles in ALI development by regulating neutrophil functions. GPR84 is highly upregulated in the cells isolated from the bronchoalveolar lavage fluid of LPS-induced ALI mice. GPR84 deficiency or blockage significantly ameliorated ALI mice lung inflammation by reducing neutrophils infiltration and oxidative stress. Further studies reveal that activation of GPR84 strongly induced reactive oxygen species production from neutrophils by stimulating Lyn, AKT and ERK1/2 activation and the assembly of the NADPH oxidase. These results reveal an important role of GPR84 in neutrophil functions and lung inflammation and strongly suggest that GPR84 is a potential drug target for ALI. |
| WOS关键词 | ACUTE LUNG INJURY ; RESPIRATORY-DISTRESS-SYNDROME ; NADPH OXIDASE ; NOX FAMILY ; RECEPTOR ; DEGRANULATION ; PATHOGENESIS ; RECRUITMENT ; ANTAGONISTS ; ACTIVATION |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | NATURE PUBL GROUP |
| WOS记录号 | WOS:000962657100001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309653]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Xie, Xin |
| 作者单位 | 1.Burgeon Therapeut Co Ltd, Shanghai 201203, Peoples R China 2.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China; 3.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Peoples R China; 4.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Hangzhou 310024, Peoples R China; 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 6.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, State Key Lab Drug Res, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Wang, Si-wei,Zhang, Qing,Lu, Dan,et al. GPR84 regulates pulmonary inflammation by modulating neutrophil functions[J]. ACTA PHARMACOLOGICA SINICA,2023,44(8):1665-1675. |
| APA | Wang, Si-wei.,Zhang, Qing.,Lu, Dan.,Fang, You-chen.,Yan, Xiao-ci.,...&Xie, Xin.(2023).GPR84 regulates pulmonary inflammation by modulating neutrophil functions.ACTA PHARMACOLOGICA SINICA,44(8),1665-1675. |
| MLA | Wang, Si-wei,et al."GPR84 regulates pulmonary inflammation by modulating neutrophil functions".ACTA PHARMACOLOGICA SINICA 44.8(2023):1665-1675. |
入库方式： OAI收割
来源：上海药物研究所
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