Rh-Catalyzed C-H Activation/Annulation of Enaminones and Cyclic 1,3-Dicarbonyl Compounds: An Access to Isocoumarins
文献类型：期刊论文
| 作者 | Wang, Qian3,4; Li, Ying3,4; Sun, Jina2,4; Chen, Shiyu1; Li, Hui3; Zhou, Yu2,4; Li, Jian3,4; Liu, Hong2,3,4
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| 刊名 | JOURNAL OF ORGANIC CHEMISTRY
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| 出版日期 | 2023-04-03 |
| 卷号 | 88期号:9页码:5348-5358 |
| DOI | 10.1021/acs.joc.2c02898 |
| 文献子类 | Article |
| 英文摘要 | A facile access to isocoumarins has been established via rhodium(III)-catalyzed C-H bond activation and intramolecular C-C cascade annulation of enaminones and cyclic 1,3-dicarbonyl compounds. The synthetic protocol features a wide range of substrates with high functional group tolerance, mild reaction conditions, and the selective cleavage of the enaminone C-C bond. Notably, the cyclic 1,3-dicarbonyl compounds can in situ-generate iodonium ylide as a carbene precursor to prepare polycyclic scaffolds by reacting with PhI(OAc)2. The application of this method to prepare useful synthetic precursors and bioactive skeletons is also exemplified. |
| WOS关键词 | SULFOXONIUM YLIDES ; ACTIVATION ; AMIDATION ; SYNTHONS ; ALKYNES |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000966272300001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309655]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Li, Jian; Liu, Hong |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Biotech Drug Res Ctr, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 4.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Wang, Qian,Li, Ying,Sun, Jina,et al. Rh-Catalyzed C-H Activation/Annulation of Enaminones and Cyclic 1,3-Dicarbonyl Compounds: An Access to Isocoumarins[J]. JOURNAL OF ORGANIC CHEMISTRY,2023,88(9):5348-5358. |
| APA | Wang, Qian.,Li, Ying.,Sun, Jina.,Chen, Shiyu.,Li, Hui.,...&Liu, Hong.(2023).Rh-Catalyzed C-H Activation/Annulation of Enaminones and Cyclic 1,3-Dicarbonyl Compounds: An Access to Isocoumarins.JOURNAL OF ORGANIC CHEMISTRY,88(9),5348-5358. |
| MLA | Wang, Qian,et al."Rh-Catalyzed C-H Activation/Annulation of Enaminones and Cyclic 1,3-Dicarbonyl Compounds: An Access to Isocoumarins".JOURNAL OF ORGANIC CHEMISTRY 88.9(2023):5348-5358. |
入库方式： OAI收割
来源：上海药物研究所
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