Extending the Record of Terpenes from Soft Coral Sarcophyton mililatensis
文献类型：期刊论文
| 作者 | Yang, Min4; Ge, Zeng-Yue3; Chen, Zi-Hui4; Yao, Li-Gong4; Liang, Lin-Fu3; Guo, Yue-Wei1,2,4
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| 刊名 | CHEMISTRY & BIODIVERSITY
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| 出版日期 | 2023-04-01 |
| 卷号 | 20期号:4 |
| 关键词 | soft coral Sarcophyton mililatensis terpene structural elucidation SARS-CoV-2 M-pro inhibitor |
| DOI | 10.1002/cbdv.202300267 |
| 文献子类 | Article |
| 英文摘要 | In the present study, a new polyoxygenated cembranoid named sarcomililatol H (1) as well as six known terpenes 2-7 with different skeletons were isolated from South China Sea soft coral Sarcophyton mililatensis. Based on the comprehensive analyses of 1D and 2D NMR spectroscopic data, the structure of the new compound 1 was established. This new cembranoid was characterized by the presence of the rarely encountered tetrahydropyran ring with the ether linkage across C-2 and C-12. By applying the time-dependent density functional theory electronic circular dichroism (TDDFT ECD) approach, the absolute configuration of sarcomililatol H (1) was determined. All of the isolates were subjected to the anti-inflammatory and anti-tumor bioassays. However, none of them was active in these evaluations. Additionally, the preliminary virtual screening of inhibitory against SARS-CoV-2 by molecular docking showed that diterpene 1 could be regarded as a SARS-CoV-2 main protease (M-pro) inhibitor (binding energy: -7.63 kcal/mol). The discovery of these terpenes has expanded the chemical diversity and complexity of terpenes from the species S. mililatensis. |
| WOS关键词 | CAPNOSANE DITERPENES ; METABOLITES ; TROCHELIOPHORUM ; INHIBITORS ; DERIVATIVES ; SARSOLENANE ; CHEMISTRY |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000961507500001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309656]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Liang, Lin-Fu; Guo, Yue-Wei |
| 作者单位 | 1.Pilot Natl Lab Marine Sci & Technol Qingdao, Open Studio Druggabil Res Marine Nat Prod, 1 Wenhai Rd, Jimo 266237, Qingdao, Peoples R China 2.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Peoples R China; 3.Cent South Univ Forestry & Technol, Coll Mat Sci & Engn, 498 South Shaoshan Rd, Changsha 410004, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd, Zhangjiang Hi Tech Pk, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Yang, Min,Ge, Zeng-Yue,Chen, Zi-Hui,et al. Extending the Record of Terpenes from Soft Coral Sarcophyton mililatensis[J]. CHEMISTRY & BIODIVERSITY,2023,20(4). |
| APA | Yang, Min,Ge, Zeng-Yue,Chen, Zi-Hui,Yao, Li-Gong,Liang, Lin-Fu,&Guo, Yue-Wei.(2023).Extending the Record of Terpenes from Soft Coral Sarcophyton mililatensis.CHEMISTRY & BIODIVERSITY,20(4). |
| MLA | Yang, Min,et al."Extending the Record of Terpenes from Soft Coral Sarcophyton mililatensis".CHEMISTRY & BIODIVERSITY 20.4(2023). |
入库方式： OAI收割
来源：上海药物研究所
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