LIM domain-containing protein Ajuba inhibits chemotherapy-induced apoptosis by negatively regulating p53 stability in colorectal cancer cells
文献类型：期刊论文
| 作者 | Xu, Beihui5; Li, Qi4; Zhang, Jianjun3; Chen, Fuxiang1,2,5 |
| 刊名 | MOLECULAR ONCOLOGY
 |
| 出版日期 | 2023-08-01 |
| 卷号 | 17期号:8页码:1678-1691 |
| 关键词 | Ajuba apoptosis chemoresistance colorectal cancer p53 |
| DOI | 10.1002/1878-0261.13421 |
| 文献子类 | Article |
| 英文摘要 | LIM protein-domain containing protein Ajuba (encoded by AJUBA) functions as a scaffold protein to regulate protein-protein interactions, signalling transduction and genes transcription. AJUBA expression is higher in colorectal cancer (CRC) tissues than normal tissues, but its specific molecular function in CRC progression is still not very clear. Here, we found that, in CRC cancer cell lines, overexpression of AJUBA decreased p53 levels, whereas knock-down of AJUBA significantly increased p53 levels. Although the presence of Ajuba did not influence p53 transcription, it formed a complex with p53 and MDM2 to promote the degradation of p53. AJUBA overexpression reduced the sensitivity of cancer cells to chemotherapeutic drugs and vice versa. In addition, chemotherapeutic drugs significantly induced AJUBA expression, which was largely dependent on the presence of p53. Therefore, Ajuba formed a negative feedback loop to regulate p53 expression and activity. In conclusion, as a novel p53-negative regulator, Ajuba inhibits the apoptosis of CRC cells induced by chemotherapeutic drugs and it may be a new therapeutic target for CRC treatment. |
| WOS关键词 | TUMOR-SUPPRESSOR ; ACTIVATION ; MUTATIONS ; CARCINOMA ; PATHWAY ; GROWTH ; GAMMA ; HEAD |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| 出版者 | WILEY |
| WOS记录号 | WOS:000962369400001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309657]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Chen, Fuxiang |
| 作者单位 | 1.639 Zhizaoju Rd, Shanghai, Peoples R China 2.Shanghai Jiao Tong Univ, Fac Med Lab Sci, Sch Med, Shanghai, Peoples R China; 3.Shanghai Jiao Tong Univ, Peoples Hosp 9, Dept Oral & Maxillofacial Head & Neck Oncol, Sch Med, Shanghai, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Beijing, Peoples R China; 5.Shanghai Jiao Tong Univ, Peoples Hosp 9, Lab Med, Sch Med, Shanghai, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Xu, Beihui,Li, Qi,Zhang, Jianjun,et al. LIM domain-containing protein Ajuba inhibits chemotherapy-induced apoptosis by negatively regulating p53 stability in colorectal cancer cells[J]. MOLECULAR ONCOLOGY,2023,17(8):1678-1691. |
| APA | Xu, Beihui,Li, Qi,Zhang, Jianjun,&Chen, Fuxiang.(2023).LIM domain-containing protein Ajuba inhibits chemotherapy-induced apoptosis by negatively regulating p53 stability in colorectal cancer cells.MOLECULAR ONCOLOGY,17(8),1678-1691. |
| MLA | Xu, Beihui,et al."LIM domain-containing protein Ajuba inhibits chemotherapy-induced apoptosis by negatively regulating p53 stability in colorectal cancer cells".MOLECULAR ONCOLOGY 17.8(2023):1678-1691. |
入库方式： OAI收割
来源：上海药物研究所
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