Living Cells and Cell-Derived Vesicles: A Trojan Horse Technique for Brain Delivery
文献类型：期刊论文
| 作者 | Ou, Ante4,5; Wang, Yuewei4,5; Zhang, Jiaxin5; Huang, Yongzhuo1,2,3,4,5
|
| 刊名 | PHARMACEUTICS
 |
| 出版日期 | 2023-04-01 |
| 卷号 | 15期号:4页码:1257 |
| 关键词 | brain drug delivery blood-brain barrier (BBB) Trojan horse delivery systems cells extracellular vesicles cell membranes |
| DOI | 10.3390/pharmaceutics15041257 |
| 文献子类 | Review |
| 英文摘要 | Brain diseases remain a significant global healthcare burden. Conventional pharmacological therapy for brain diseases encounters huge challenges because of the blood-brain barrier (BBB) limiting the delivery of therapeutics into the brain parenchyma. To address this issue, researchers have explored various types of drug delivery systems. Cells and cell derivatives have attracted increasing interest as Trojan horse delivery systems for brain diseases, owing to their superior biocompatibility, low immunogenicity, and BBB penetration properties. This review provided an overview of recent advancements in cell- and cell-derivative-based delivery systems for the diagnosis and treatment of brain diseases. Additionally, it discussed the challenges and potential solutions for clinical translation. |
| WOS关键词 | DRUG-DELIVERY ; EXTRACELLULAR VESICLES ; MACROPHAGE MEMBRANE ; TARGETED DELIVERY ; ANTICANCER DRUG ; CANCER-THERAPY ; EXOSOMES ; NANOPARTICLES ; NANOCARRIERS ; NEUTROPHILS |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000979306800001 |
| 出版者 | MDPI |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309658]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Huang, Yongzhuo |
| 作者单位 | 1.Southern Med Univ, Sch Pharmaceut Sci, Guangzhou 510515, Peoples R China 2.NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipie, Shanghai 201203, Peoples R China; 3.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528437, Peoples R China; 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 5.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Ou, Ante,Wang, Yuewei,Zhang, Jiaxin,et al. Living Cells and Cell-Derived Vesicles: A Trojan Horse Technique for Brain Delivery[J]. PHARMACEUTICS,2023,15(4):1257. |
| APA | Ou, Ante,Wang, Yuewei,Zhang, Jiaxin,&Huang, Yongzhuo.(2023).Living Cells and Cell-Derived Vesicles: A Trojan Horse Technique for Brain Delivery.PHARMACEUTICS,15(4),1257. |
| MLA | Ou, Ante,et al."Living Cells and Cell-Derived Vesicles: A Trojan Horse Technique for Brain Delivery".PHARMACEUTICS 15.4(2023):1257. |
入库方式： OAI收割
来源：上海药物研究所
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