Peptide-functionalized therapeutic nanoplatform for treatment orthotopic triple negative breast cancer and bone metastasis
文献类型：期刊论文
| 作者 | Li, Daifeng6; Ma, Shengnan6; Xu, Denghui6; Meng, Xiaocao5; Lei, Ningjing5; Liu, Chen5; Zhao, Ying1,2; Qi, Yingqiu5; Cheng, Zhen3,4; Wang, Fazhan6 |
| 刊名 | NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
 |
| 出版日期 | 2023-06-01 |
| 卷号 | 50页码:102669 |
| 关键词 | Triple-negative breast cancer Epidermal growth factor receptor Peptide-functionalized therapy Peptide self-assembly Nanoplatform |
| DOI | 10.1016/j.nano.2023.102669 |
| 文献子类 | Article |
| 英文摘要 | Epidermal Growth Factor Receptor (EGFR) is a promising therapeutic target for triple-negative breast cancer (TNBC). Recently, specific EGFR-targeting peptide GE11-based delivery nano-system shows excellent potential because of its chemical versatility and good targeting ability. However, no further research focusing on the downstream of EGFR after binding with GE11 was explored. Hence, we tailor-designed a self-assembled nanoplatform named GENP using amphiphilic molecule of stearic acid-modified GE11. After loading doxorubicin (DOX), the resulted nanoplatform GENP@DOX demonstrated high loading efficiency and sustainable drug release. Importantly, our findings proved that GENP alone significantly suppressed the proliferation of MDA-MB-231 cells via EGFR-downstream PI3K/AKT signaling pathways, contributing to the synergistic treatment with its DOX release. Further work illustrated remarkable therapeutic efficacy both in orthotopic TNBC and its bone metastasis models with minimal biotoxicity. Together, the results highlight that our GENP-functionalized nanoplatform is a promising strategy for the synergistic therapeutic efficacy targeting EGFR-overexpressed cancer. & COPY; 2023 Published by Elsevier Inc. |
| WOS关键词 | GROWTH-FACTOR RECEPTOR ; HYALURONIC-ACID ; EGFR ; IDENTIFICATION ; NANOPARTICLES ; PENETRATION ; ACTIVATION ; LIPOSOMES ; MICELLES ; EFFICACY |
| WOS研究方向 | Science & Technology - Other Topics ; Research & Experimental Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:001041598100001 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309660]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Qi, Yingqiu; Cheng, Zhen; Wang, Fazhan |
| 作者单位 | 1.Natl Ctr Nanosci & Technol, Ctr Excellence Nanosci, Beijing 100190, Peoples R China 2.Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China; 3.Bohai Rim Adv Res Inst Drug Discovery, Drug Discovery Shandong Lab, Yantai 264117, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med Chinese Acad Sci, Mol Imaging Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 5.Zhengzhou Univ, Sch Basic Med Sci, Dept Pharmacol, Zhengzhou 450001, Peoples R China; 6.Zhengzhou Univ, Affiliated Hosp 1, Med Res Ctr, Dept Orthoped, Zhengzhou 450052, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Li, Daifeng,Ma, Shengnan,Xu, Denghui,et al. Peptide-functionalized therapeutic nanoplatform for treatment orthotopic triple negative breast cancer and bone metastasis[J]. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,2023,50:102669. |
| APA | Li, Daifeng.,Ma, Shengnan.,Xu, Denghui.,Meng, Xiaocao.,Lei, Ningjing.,...&Wang, Fazhan.(2023).Peptide-functionalized therapeutic nanoplatform for treatment orthotopic triple negative breast cancer and bone metastasis.NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,50,102669. |
| MLA | Li, Daifeng,et al."Peptide-functionalized therapeutic nanoplatform for treatment orthotopic triple negative breast cancer and bone metastasis".NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE 50(2023):102669. |
入库方式： OAI收割
来源：上海药物研究所
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