Chemistry, Chemo-Ecology, and Biological Activities of Uncommon and Structurally Diverse Sesquiterpenoids from the Sanya Bay Nudibranch Hexabranchus sanguineus
文献类型：期刊论文
| 作者 | Shen, Shou-Mao3,4,6; Su, Ming-Zhi5; Yu, Dan-Dan5; Luo, Hui2; Li, Xu-Wen5,6 ; Guo, Yue-Wei1,3,5,6
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| 刊名 | CHEMISTRY-A EUROPEAN JOURNAL
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| 出版日期 | 2023-05-16 |
| 卷号 | 29期号:28 |
| 关键词 | glycinyl-lactam Hexabranchus sanguineus nudibranch sesquiterpenoids structural revision |
| DOI | 10.1002/chem.202300457 |
| 文献子类 | Article |
| 英文摘要 | A detailed chemical investigation of the Sanya Bay nudibranch Hexabranchus sanguineus yielded thirteen new sesquiterpenoids, namely sanyagunins A-H, sanyalides A-C, and sanyalactams A and B, along with eleven known related ones. Sanyalactams A and B feature an unprecedented hexahydrospiro[indene-2,3 '-pyrrolidine] core. The structures of new compounds were established by a combination of extensive spectroscopic data analysis, quantum mechanical-nuclear magnetic resonance methods, the modified Mosher's method, and X-ray diffraction analysis. Based on analysis of NOESY correlations and the modified Mosher's method, the stereochemistry of two known furodysinane-type sesquiterpenoids were revised. A plausible biogenetic relationship between these sesquiterpenoids wasproposed and discussed, and a chemo-ecological relationship of the title animal and its possible sponge preys has been analyzed. In bioassays, sanyagunin B showed moderate antibacterial activity, whereas 4 alpha-formamidogorgon-11-ene exhibited potent cytotoxicity with IC50 values ranging from 0.87 to 1.95 mu M. |
| WOS关键词 | AUSTRALIAN MARINE SPONGE ; METABOLITES ; FURANOSESQUITERPENES ; PUSTULOSA ; FURANS |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000961566800001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309662]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Li, Xu-Wen; Guo, Yue-Wei |
| 作者单位 | 1.Zhejiang Univ Technol, Coll Pharmaceut Sci, Collaborat Innovat Ctr Yangtze River Delta Reg Gre, Hangzhou 310014, Peoples R China 2.Guangdong Med Univ, Marine Biomed Res Inst, Guangdong Key Lab Res & Dev Nat Drugs, Zhanjiang 524023, Peoples R China; 3.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China; 4.Yancheng Teachers Univ, Sch Pharm, Yancheng 224002, Peoples R China; 5.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China; 6.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Shen, Shou-Mao,Su, Ming-Zhi,Yu, Dan-Dan,et al. Chemistry, Chemo-Ecology, and Biological Activities of Uncommon and Structurally Diverse Sesquiterpenoids from the Sanya Bay Nudibranch Hexabranchus sanguineus[J]. CHEMISTRY-A EUROPEAN JOURNAL,2023,29(28). |
| APA | Shen, Shou-Mao,Su, Ming-Zhi,Yu, Dan-Dan,Luo, Hui,Li, Xu-Wen,&Guo, Yue-Wei.(2023).Chemistry, Chemo-Ecology, and Biological Activities of Uncommon and Structurally Diverse Sesquiterpenoids from the Sanya Bay Nudibranch Hexabranchus sanguineus.CHEMISTRY-A EUROPEAN JOURNAL,29(28). |
| MLA | Shen, Shou-Mao,et al."Chemistry, Chemo-Ecology, and Biological Activities of Uncommon and Structurally Diverse Sesquiterpenoids from the Sanya Bay Nudibranch Hexabranchus sanguineus".CHEMISTRY-A EUROPEAN JOURNAL 29.28(2023). |
入库方式： OAI收割
来源：上海药物研究所
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