Modular Click Assembly DNA-Encoded Glycoconjugate Libraries with on-DNA Functional Group Transformations
文献类型：期刊论文
| 作者 | Ling, Xing3,4; Liu, Sixiu3,4; Yang, Yixuan4; Dong, Qian2; Marcaurelle, Lisa A.1; Huang, Wei2; Ding, Yun1; Wang, Xuan4; Lu, Xiaojie3,4
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| 刊名 | BIOCONJUGATE CHEMISTRY
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| 出版日期 | 2023-04-19 |
| 卷号 | 34期号:4页码:616-620 |
| DOI | 10.1021/acs.bioconjchem.3c00068 |
| 文献子类 | Article |
| 英文摘要 | Carbohydrates are an important class of naturally active products and play vital roles in regulating various physiological activities. To meet the demand for carbohydrate-based libraries used for the identification of potential drug candidates for pharmaceutical-related targets, we developed a set of on-DNA protocols to construct the DNA-encoded glycoconjugates, including Seyferth-Gilbert homologation, anomeric azidation, and CuAAC cyclization. These on-DNA chemistries enable the generation and modification of DNA-linked glycosyl compounds with good conversions and broad substrate scope. Finally, three DNA-linked glycoconjugate libraries were successfully generated to demonstrate their applicability and feasibility in library preparation. |
| WOS关键词 | CHEMISTRY |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000960449000001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309663]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Ding, Yun; Wang, Xuan; Lu, Xiaojie |
| 作者单位 | 1.GlaxoSmithKline, ELT NCE Mol Discovery Med Sci & Technol, Cambridge, MA 02410 USA 2.Chinese Acad Sci, CAS Key Lab Receptor Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 3.Univ Chinese Sci, Beijing 100049, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 100049, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Ling, Xing,Liu, Sixiu,Yang, Yixuan,et al. Modular Click Assembly DNA-Encoded Glycoconjugate Libraries with on-DNA Functional Group Transformations[J]. BIOCONJUGATE CHEMISTRY,2023,34(4):616-620. |
| APA | Ling, Xing.,Liu, Sixiu.,Yang, Yixuan.,Dong, Qian.,Marcaurelle, Lisa A..,...&Lu, Xiaojie.(2023).Modular Click Assembly DNA-Encoded Glycoconjugate Libraries with on-DNA Functional Group Transformations.BIOCONJUGATE CHEMISTRY,34(4),616-620. |
| MLA | Ling, Xing,et al."Modular Click Assembly DNA-Encoded Glycoconjugate Libraries with on-DNA Functional Group Transformations".BIOCONJUGATE CHEMISTRY 34.4(2023):616-620. |
入库方式： OAI收割
来源：上海药物研究所
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