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Iodine substitution compromises the aggregation-induced emission (AIE) property and enhances the biothiol sensitivity of quinoline-malononitrile-based fluorescent probes

文献类型：期刊论文

作者Zhu, Guo-Biao5,6; Gao, Jie5,6; Zhang, Min-Yu5,6; He, Liu5,6; Han, Hai-Hao5,6; Zang, Yi1,2,4; Li, Jia1,4; He, Xiao-Peng3,5,6
刊名DYES AND PIGMENTS
出版日期2023-07-01
卷号215页码:111246
关键词Fluorescent probes Biothiol Cell imaging Aggregation-induced emission Donor-Acceptor
DOI10.1016/j.dyepig.2023.111246
文献子类Article
英文摘要The development of long-wavelength fluorescent probes with a pH working range from weakly acidic to neutral is important for cell-imaging studies. In this study, quinoline-malononitrile (QM)-based fluorescent probes without and with iodine substitution surrounding its phenolic ring are synthesized. The iodine substitution manner was found to compromise the aggregation-induced emission of QM whilst resulting in a significantly enhanced sensitivity for biothiols including L-cystine (L-Cys) detection in weakly acidic to neutral aqueous buffer solutions through reducing the pKa of the QM fluorogen. The probe also effectively achieved the fluorescence visualization of the fluctuation in L-Cys levels in cells.
WOS关键词RATIOMETRIC DETECTION ; SELECTIVE DETECTION ; CYSTEINE ; GLUTATHIONE ; LECTINS ; BIOLOGY ; RED
WOS研究方向Chemistry ; Engineering ; Materials Science
语种英语
WOS记录号WOS:000959918900001
出版者ELSEVIER SCI LTD
源URL[http://119.78.100.183/handle/2S10ELR8/309665]  
专题新药研究国家重点实验室
通讯作者Zang, Yi; Li, Jia; He, Xiao-Peng
作者单位1.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Hangzhou 310024, Peoples R China
2.Lingang Lab, Shanghai 201203, Peoples R China;
3.Eastern Hepatobiliary Surg Hosp, Natl Ctr Liver Canc, Int Cooperat Lab Signal Transduct, Shanghai 200438, Peoples R China;
4.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, State Key Lab Drug Res, Shanghai 201203, Peoples R China;
5.East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Frontiers Ctr Materiobiol & Dynam Chem, Joint Int Res Lab Precis Chem & Mol Engn,Sch Chem, 130 Meilong RD, Shanghai 200237, Peoples R China;
6.East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Frontiers Ctr Materiobiol & Dynam Chem, Sch Chem & Mol Engn,Key Lab Adv Mat, 130 Meilong RD, Shanghai 200237, Peoples R China;
推荐引用方式
GB/T 7714		 Zhu, Guo-Biao,Gao, Jie,Zhang, Min-Yu,et al. Iodine substitution compromises the aggregation-induced emission (AIE) property and enhances the biothiol sensitivity of quinoline-malononitrile-based fluorescent probes[J]. DYES AND PIGMENTS,2023,215:111246.
APA Zhu, Guo-Biao.,Gao, Jie.,Zhang, Min-Yu.,He, Liu.,Han, Hai-Hao.,...&He, Xiao-Peng.(2023).Iodine substitution compromises the aggregation-induced emission (AIE) property and enhances the biothiol sensitivity of quinoline-malononitrile-based fluorescent probes.DYES AND PIGMENTS,215,111246.
MLA Zhu, Guo-Biao,et al."Iodine substitution compromises the aggregation-induced emission (AIE) property and enhances the biothiol sensitivity of quinoline-malononitrile-based fluorescent probes".DYES AND PIGMENTS 215(2023):111246.

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来源：上海药物研究所

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