Nanolobatone A, An Unprecedented Diterpenoid and Related New Casbanoids from the Hainan Soft Coral Sinularia nanolobata
文献类型：期刊论文
| 作者 | Liu, Jiao4,5; Li, Song-Wei3; Zhao, Qing-Min4,5; Zhang, Zai-Yong5; Yao, Li-Gong5; Gu, Yu-Cheng2; Lan, Le-Fu4,5 ; Guo, Yue-Wei1,4,5
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| 刊名 | CHEMISTRY-A EUROPEAN JOURNAL
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| 出版日期 | 2023-05-08 |
| 卷号 | 29期号:26 |
| 关键词 | bioactivity diterpenoid Sinularia soft coral stereochemistry |
| DOI | 10.1002/chem.202300055 |
| 文献子类 | Article |
| 英文摘要 | Nanolobatone A, featuring an unprecedented tricyclo[10.3.0.0(1,2)]pentadecane carbon skeleton, along with four new polyoxygenated and four unusual endoperoxide-bridged casbane-type diterpenoids were isolated from the Hainan soft coral Sinularia nanolobata. The structures of the new compounds were established by extensive spectroscopic analysis, X-ray diffraction analysis, and time-dependent density functional theory/electronic circular dichroism calculations. A plausible biosynthetic pathway of new isolates was proposed. Bioassays revealed that nanolobatone A showed weak antibacterial activity against the Gram-positive bacteria Streptococcus pyogenes. |
| WOS关键词 | CROTON-NEPETAEFOLIUS ; TERPENOIDS |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| WOS记录号 | WOS:000951754800001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309666]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Guo, Yue-Wei |
| 作者单位 | 1.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China 2.Syngenta, Jealotts Hill Int Res Ctr, Bracknell RG42 6EY, Berks, England; 3.Zhejiang Univ Technol, Coll Pharmaceut Sci, 18 Chaowang Rd, Hangzhou 310014, Peoples R China; 4.Univ Chinese Acad Sci, 19 A Yuquan Rd, Beijing 100049, Peoples R China; 5.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Liu, Jiao,Li, Song-Wei,Zhao, Qing-Min,et al. Nanolobatone A, An Unprecedented Diterpenoid and Related New Casbanoids from the Hainan Soft Coral Sinularia nanolobata[J]. CHEMISTRY-A EUROPEAN JOURNAL,2023,29(26). |
| APA | Liu, Jiao.,Li, Song-Wei.,Zhao, Qing-Min.,Zhang, Zai-Yong.,Yao, Li-Gong.,...&Guo, Yue-Wei.(2023).Nanolobatone A, An Unprecedented Diterpenoid and Related New Casbanoids from the Hainan Soft Coral Sinularia nanolobata.CHEMISTRY-A EUROPEAN JOURNAL,29(26). |
| MLA | Liu, Jiao,et al."Nanolobatone A, An Unprecedented Diterpenoid and Related New Casbanoids from the Hainan Soft Coral Sinularia nanolobata".CHEMISTRY-A EUROPEAN JOURNAL 29.26(2023). |
入库方式： OAI收割
来源：上海药物研究所
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