Antitumor Cembrane Diterpenoids from the South China Sea Soft Coral Lobophytum sp.
文献类型：期刊论文
| 作者 | Song, Yu-Ting5,6; Yu, Dan-Dan3; Zhi Su, Ming3; Luo, Hui1; Cao, Jian-Guo6; Yao, Li-Gong5; Liang, Lin-Fu4; Guo, Yue-Wei2,3,5 ; Yang, Fan6
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| 刊名 | CHEMISTRY & BIODIVERSITY
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| 出版日期 | 2023-04-01 |
| 卷号 | 20期号:4 |
| 关键词 | soft coral Lobophytum sp cembranoids configuration determination antitumor activity |
| DOI | 10.1002/cbdv.202300217 |
| 文献子类 | Article |
| 英文摘要 | Two new highly functionalized cembrane diterpenoids named ximaolobophytolides A (1) and B (2) as minor components, together with seven related known compounds (3-9), have been isolated and identified from the Ximao soft coral Lobophytum sp. They were characterized by the presence of an alpha-methylene-gamma-lactone moiety. Based on the comprehensive analyses of 1D and 2D NMR spectroscopic data, the absolute configurations of these two new compounds were elucidated by the combination of quantum mechanical (QM)-NMR and time-dependent density functional theory/electronic circular dichroism (TDDFT-ECD) calculation approaches. In the anti-tumor bioassays, compounds 3-9 showed moderate to significant inhibitory effects (IC50 values ranging from 29.66 to 0.39 mu M) against the proliferations of five tumor cells HEL, A549, H1975, MDA-MB-231, and H1299. It might be worthy to point out that compounds 4, 7, and 8 exhibited better anti-tumor activities than that of the positive control Doxorubicin. |
| WOS关键词 | C-13 CHEMICAL-SHIFTS ; TERPENOIDS |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| WOS记录号 | WOS:000947786300001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309673]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Liang, Lin-Fu; Guo, Yue-Wei; Yang, Fan |
| 作者单位 | 1.Guangdong Med Univ, Marine Biomed Res Inst, Key Lab Zhanjiang Res & Dev Marine Microbial Resou, Zhanjiang 524023, Peoples R China 2.Pilot Natl Lab Marine Sci & Technol Qingdao, Open Studio Druggabil Res Marine Nat Prod, 1 Wenhai Rd,Aoshanwei, Qingdao 266237, Peoples R China; 3.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Peoples R China; 4.Cent South Univ Forestry & Technol, Coll Mat Sci & Engn, 498 South Shaoshan Rd, Changsha 410004, Peoples R China; 5.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China; 6.Shanghai Normal Univ, Coll Life Sci, Biol Dept, 100 Guilin Rd, Shanghai 200234, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Song, Yu-Ting,Yu, Dan-Dan,Zhi Su, Ming,et al. Antitumor Cembrane Diterpenoids from the South China Sea Soft Coral Lobophytum sp.[J]. CHEMISTRY & BIODIVERSITY,2023,20(4). |
| APA | Song, Yu-Ting.,Yu, Dan-Dan.,Zhi Su, Ming.,Luo, Hui.,Cao, Jian-Guo.,...&Yang, Fan.(2023).Antitumor Cembrane Diterpenoids from the South China Sea Soft Coral Lobophytum sp..CHEMISTRY & BIODIVERSITY,20(4). |
| MLA | Song, Yu-Ting,et al."Antitumor Cembrane Diterpenoids from the South China Sea Soft Coral Lobophytum sp.".CHEMISTRY & BIODIVERSITY 20.4(2023). |
入库方式： OAI收割
来源：上海药物研究所
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