Structurally Diverse Diterpenoids from the Sanya Bay Nudibranch Hexabranchus sanguineus and Its Sponge-Prey Chelonaplysilla sp.
文献类型：期刊论文
| 作者 | Shen, Shou-Mao5,6; Li, Song-Wei3,4; Su, Ming-Zhi2; Yao, Li-Gong6; Appendino, Giovanni1; Guo, Yue-Wei2,5,6
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| 刊名 | CHEMISTRY-A EUROPEAN JOURNAL
 |
| 出版日期 | 2023-04-13 |
| 卷号 | 29期号:21 |
| 关键词 | Chelonaplysilla sp chemical ecology diterpenoid Hexabranchus sanguineus nudibranch |
| DOI | 10.1002/chem.202203858 |
| 文献子类 | Article |
| 英文摘要 | Investigation of the South China Sea nudibranch Hexabranchus sanguineus from Sanya Bay afforded, in addition to three known compounds, nine new diterpenoids of the 5,19-cycloclerodane- (sanyanolides A-D), clerodane- (sanyanolide E) and subersin- (sanyanolides F-I) type. Remarkably, six diterpenoids aforementioned from H. sanguineus were also isolated from the sponge Chelonaplysilla sp. from the same water region, suggesting a trophic relationship between H. sanguineus and Chelonaplysilla sp. The structure and absolute configuration of new compounds were established by a combination of spectroscopic data, X-ray diffraction analysis and/or time-dependent density functional theory/electronic circular dichroism calculations. A plausible biogenetic relationship between these diterpenoids, along with the chemo-ecological implications of their co-occurrence in the two organisms investigated, was proposed and discussed. In in vitro bioassays, echinoclerodane A exhibited a potent inhibitory effect (IC50=2.81 mu M) on LPS-induced inflammatory response in RAW 264.7 macrophage cells. In addition, echinoclerodane A and oculatolide showed considerable antibacterial activities with MIC values ranging from 1.0 to 8.0 mu g/mL. |
| WOS关键词 | CLERODANE DITERPENES ; METABOLITES ; MACROLIDES |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000945489900001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309678]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Guo, Yue-Wei |
| 作者单位 | 1.Univ Piemonte Orientale, Dipartimento Sci Farmaco, Largo Donegani 2, I-28100 Novara, Italy 2.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China; 3.Zhejiang Univ Technol, Collaborat Innovat Ctr Yangtze River Delta Reg Gre, Hangzhou 310014, Peoples R China; 4.Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Peoples R China; 5.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China; 6.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd, Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Shen, Shou-Mao,Li, Song-Wei,Su, Ming-Zhi,et al. Structurally Diverse Diterpenoids from the Sanya Bay Nudibranch Hexabranchus sanguineus and Its Sponge-Prey Chelonaplysilla sp.[J]. CHEMISTRY-A EUROPEAN JOURNAL,2023,29(21). |
| APA | Shen, Shou-Mao,Li, Song-Wei,Su, Ming-Zhi,Yao, Li-Gong,Appendino, Giovanni,&Guo, Yue-Wei.(2023).Structurally Diverse Diterpenoids from the Sanya Bay Nudibranch Hexabranchus sanguineus and Its Sponge-Prey Chelonaplysilla sp..CHEMISTRY-A EUROPEAN JOURNAL,29(21). |
| MLA | Shen, Shou-Mao,et al."Structurally Diverse Diterpenoids from the Sanya Bay Nudibranch Hexabranchus sanguineus and Its Sponge-Prey Chelonaplysilla sp.".CHEMISTRY-A EUROPEAN JOURNAL 29.21(2023). |
入库方式： OAI收割
来源：上海药物研究所
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