Spatial-Drug-Laden Protease-Activatable M1 Macrophage System Targets Lung Metastasis and Potentiates Antitumor Immunity
文献类型：期刊论文
| 作者 | Xu, Xiaoxuan4,5; Wang, Qiang3; Qian, Xindi4,5; Wu, Yao1,2; Wang, Jiaoying5; Li, Jie5; Li, Yaping4,5 ; Zhang, Zhiwen1,2
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| 刊名 | ACS NANO
 |
| 出版日期 | 2023-03-28 |
| 卷号 | 17期号:6页码:5354-5372 |
| 关键词 | M1 macrophages lung metastasis antitumor immunity fibroblast activation protein protease liposome |
| DOI | 10.1021/acsnano.2c08834 |
| 文献子类 | Article |
| 英文摘要 | Lung metastasis is a critical cause of cancer mortality and its therapy is largely challenged by the limited drug delivery efficiency and robust immunosuppression in metastatic tumors. Herein, we designed a spatial-drug-laden M1 macrophage system with liposomal R848 inside and fibroblast activation protein protease (FAP)-sensitive phospholipid-DM4 conjugate on the membrane of M1 macrophage (RDM). RDM could preferentially accumulate at the metastatic lesions in lungs and responsively release the therapeutic agents as free drug molecules or drug-loaded nanovesicles. RDM treatment notably enhanced the infiltration of CD3+CD8+ T cells to lung metastasis and, respectively, caused an 8.54-, 12.87-and 2.85-fold improvement of the granzyme-B-, interferon-gamma-, and Ki67-positive subtypes versus negative control. Moreover, RDM treatment produced a 90.99% inhibition of lung metastasis in 4T1 models and significant prolongation of survival in three murine lung metastatic models. Therefore, the drug-laden FAP-sensitive M1 macrophage system represents a feasible strategy to target lung metastasis and boost antitumor immunity for antimetastasis therapy. |
| WOS关键词 | CANCER ; CELLS |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000945147300001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309680]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zhang, Zhiwen |
| 作者单位 | 1.Fudan Univ, Key Lab Smart Drug Delivery, Minist Educ, Shanghai 201203, Peoples R China 2.Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China; 3.Shanghai Univ Med & Hlth Sci, Affiliated Zhoupu Hosp, Dept Cardiothorac Surg, Shanghai 200125, Peoples R China; 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 5.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Xu, Xiaoxuan,Wang, Qiang,Qian, Xindi,et al. Spatial-Drug-Laden Protease-Activatable M1 Macrophage System Targets Lung Metastasis and Potentiates Antitumor Immunity[J]. ACS NANO,2023,17(6):5354-5372. |
| APA | Xu, Xiaoxuan.,Wang, Qiang.,Qian, Xindi.,Wu, Yao.,Wang, Jiaoying.,...&Zhang, Zhiwen.(2023).Spatial-Drug-Laden Protease-Activatable M1 Macrophage System Targets Lung Metastasis and Potentiates Antitumor Immunity.ACS NANO,17(6),5354-5372. |
| MLA | Xu, Xiaoxuan,et al."Spatial-Drug-Laden Protease-Activatable M1 Macrophage System Targets Lung Metastasis and Potentiates Antitumor Immunity".ACS NANO 17.6(2023):5354-5372. |
入库方式： OAI收割
来源：上海药物研究所
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