Pd(II) Complexes of Chiral Proline-Derived Ligands: Application for Dynamic Thermodynamic Resolution of α-Amino Acids and Their Antibacterial Activities
文献类型：期刊论文
| 作者 | Zhu, Huajian6,7; Wang, Jiang3,4,5 ; Lu, Yunfu5; Soloshonok, Vadim A.1,2; Lan, Lefu3,5; Xu, Jinyi6,7; Liu, Hong3,5,6,7
|
| 刊名 | JOURNAL OF ORGANIC CHEMISTRY
 |
| 出版日期 | 2023-03-03 |
| 卷号 | 88期号:6页码:3808-3821 |
| DOI | 10.1021/acs.joc.3c00008 |
| 文献子类 | Article |
| 英文摘要 | Novel type of Pd(II) complexes have been synthesized under operationally simple and convenient conditions and applied in the dynamic thermodynamic resolution of racemic N,C-unprotected alpha-amino acids. After rapid hydrolysis, these Pd(II) complexes produced the corresponding alpha-amino acids in satisfactory yields and enantioselectivities, accompanied by the recyclable proline-derived ligand. In addition, the method can be readily applied for S/R interconversion to obtain unnatural (R)-alpha-amino acids from readily available (S)-alpha-amino acids. Furthermore, biological assays showed that Pd(II) complexes (S,S)-3i and (S,S)-3m exhibited significant antibacterial activities similar to vancomycin, which may represent promising lead structures for further development of antibacterial agents. |
| WOS关键词 | ASYMMETRIC-SYNTHESIS ; KINETIC RESOLUTION ; SCHIFF-BASE ; S/R INTERCONVERSION ; GENERAL-METHOD ; NI(II) ; PALLADIUM ; CATALYSTS ; GLYCINE ; DESIGN |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000944556900001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309682]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Lan, Lefu; Xu, Jinyi; Liu, Hong |
| 作者单位 | 1.Basque Fdn Sci, IKERBASQUE, Bilbao 48013, Spain 2.Univ Basque Country UPV EHU, Fac Chem, Dept Organ Chem 1, San Sebastian 20018, Spain; 3.UCAS, Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Hangzhou 310024, Peoples R China; 4.Lingang Lab, Shanghai 200031, Peoples R China; 5.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 6.China Pharmaceut Univ, Dept Med Chem, Nanjing 210009, Peoples R China; 7.China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhu, Huajian,Wang, Jiang,Lu, Yunfu,et al. Pd(II) Complexes of Chiral Proline-Derived Ligands: Application for Dynamic Thermodynamic Resolution of α-Amino Acids and Their Antibacterial Activities[J]. JOURNAL OF ORGANIC CHEMISTRY,2023,88(6):3808-3821. |
| APA | Zhu, Huajian.,Wang, Jiang.,Lu, Yunfu.,Soloshonok, Vadim A..,Lan, Lefu.,...&Liu, Hong.(2023).Pd(II) Complexes of Chiral Proline-Derived Ligands: Application for Dynamic Thermodynamic Resolution of α-Amino Acids and Their Antibacterial Activities.JOURNAL OF ORGANIC CHEMISTRY,88(6),3808-3821. |
| MLA | Zhu, Huajian,et al."Pd(II) Complexes of Chiral Proline-Derived Ligands: Application for Dynamic Thermodynamic Resolution of α-Amino Acids and Their Antibacterial Activities".JOURNAL OF ORGANIC CHEMISTRY 88.6(2023):3808-3821. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。