Goliath induces inflammation in obese mice by linking fatty acid β-oxidation to glycolysis
文献类型：期刊论文
| 作者 | Hao, Shumeng6; Zhang, Sulin5; Ye, Jialin6; Chen, Lifan5; Wang, Yan6; Pei, Siyu4,6; Zhu, Qingchen6; Xu, Jing6; Tao, Yongzhen6; Zhou, Neng2,3 |
| 刊名 | EMBO REPORTS
 |
| 出版日期 | 2023-04-05 |
| 卷号 | 24期号:4 |
| 关键词 | FAO glycolysis Goliath inflammation obesity |
| DOI | 10.15252/embr.202356932 |
| 文献子类 | Article |
| 英文摘要 | Obesity is associated with metabolic disorders and chronic inflammation. However, the obesity-associated metabolic contribution to inflammatory induction remains elusive. Here, we show that, compared with lean mice, CD4(+) T cells from obese mice exhibit elevated basal levels of fatty acid beta-oxidation (FAO), which promote T cell glycolysis and thus hyperactivation, leading to enhanced induction of inflammation. Mechanistically, the FAO rate-limiting enzyme carnitine palmitoyltransferase 1a (Cpt1a) stabilizes the mitochondrial E3 ubiquitin ligase Goliath, which mediates deubiquitination of calcineurin and thus enhances activation of NF-AT signaling, thereby promoting glycolysis and hyperactivation of CD4(+) T cells in obesity. We also report the specific GOLIATH inhibitor DC-Gonib32, which blocks this FAO-glycolysis metabolic axis in CD4(+) T cells of obese mice and reduces the induction of inflammation. Overall, these findings establish a role of a Goliath-bridged FAO-glycolysis axis in mediating CD4(+) T cell hyperactivation and thus inflammation in obese mice. |
| WOS关键词 | T-CELL MEMORY ; ADAPTIVE IMMUNITY ; DIFFERENTIATION ; EXPANSION ; KINASE |
| WOS研究方向 | Biochemistry & Molecular Biology ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000942333900001 |
| 出版者 | WILEY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309684]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zheng, Mingyue; Xiao, Yichuan |
| 作者单位 | 1.Jiangsu Univ, Affiliated Hosp, Dept Nucl Med, Zhenjiang, Peoples R China 2.Shanghai Jiao Tong Univ, Pediat Translat Med Inst, Shanghai Childrens Med Ctr, Sch Med, Shanghai, Peoples R China; 3.Shanghai Jiao Tong Univ, Shanghai Childrens Med Ctr, Sch Med, Key Lab Pediat Hematol & Oncol,Minist Hlth, Shanghai, Peoples R China; 4.Shanghai Jiao Tong Univ, Shanghai Chest Hosp, Shanghai Lung Canc Ctr, Dept Thorac Surg Oncol,Sch Med, Shanghai, Peoples R China; 5.Univ Chinese Acad Sci, Shanghai, Peoples R China; 6.Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Nutr & Hlth, CAS Key Lab Tissue Microenvironm & Tumor, Shanghai, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Hao, Shumeng,Zhang, Sulin,Ye, Jialin,et al. Goliath induces inflammation in obese mice by linking fatty acid β-oxidation to glycolysis[J]. EMBO REPORTS,2023,24(4). |
| APA | Hao, Shumeng.,Zhang, Sulin.,Ye, Jialin.,Chen, Lifan.,Wang, Yan.,...&Xiao, Yichuan.(2023).Goliath induces inflammation in obese mice by linking fatty acid β-oxidation to glycolysis.EMBO REPORTS,24(4). |
| MLA | Hao, Shumeng,et al."Goliath induces inflammation in obese mice by linking fatty acid β-oxidation to glycolysis".EMBO REPORTS 24.4(2023). |
入库方式： OAI收割
来源：上海药物研究所
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