Sodium Oligomannate Electrostatically Binds to Aβ and Blocks Its Aggregation
文献类型：期刊论文
| 作者 | Zhou, Chen6; Zhang, Jingjing4,5; Luo, Xinwen3,6; Lian, Fulin6; Zeng, Yangyang2; Zhang, Zhenqing1; Zhang, Haiyan4,5 ; Zhang, Naixia3,6
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| 刊名 | JOURNAL OF PHYSICAL CHEMISTRY B
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| 出版日期 | 2023-02-27 |
| DOI | 10.1021/acs.jpcb.3c00280 |
| 文献子类 | Article |
| 英文摘要 | GV-971 (sodium oligomannate) is a China Food and Drug Administration (CFDA)-approved drug for treating Alzheimer's disease, and it could inhibit Afi fibril formation in vitro and in mouse studies. To elucidate the mechanisms for understanding how GV-971 modulates Afi's aggregation, we conducted a systematic biochemical and biophysical study of Afi40/Afi42:GV-971 systems. The integrating analysis of pre-viously published data and our results suggests that the multisite electrostatic interactions between GV-971's carboxylic groups and Afi40/Afi42's three histidine residues might play a dominant role in driving the binding of GV-971 to Afi. The fuzzy-type electrostatic interactions between GV-971 and Afi are expected to protect Afi from aggregation potentially through breaking the histidine-mediated inter-Afi electrostatic interactions. Meanwhile, since GV-971's binding exhibited a slight downregulation effect on the flexibility of Afi's histidine-colonized fragment, which potentially favors Afi aggregation, we conclude that the dynamics alteration plays a minor role in GV-971's modulation on Afi aggregation. |
| WOS关键词 | AMYLOID-BETA-PEPTIDE ; ALZHEIMERS-DISEASE BRAIN ; A-BETA ; EXPERIMENTAL CONSTRAINTS ; SECONDARY STRUCTURE ; TERMINAL REGION ; AMINO-ACIDS ; HEPARIN ; MODEL ; PH |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000939491900001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309687]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zhang, Haiyan; Zhang, Naixia |
| 作者单位 | 1.Soochow Univ, Sch Pharmaceut Sci, Suzhou 215123, Jiangsu, Peoples R China 2.Green Valley Shanghai Pharmaceut Co Ltd, Shanghai 201203, Peoples R China; 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 5.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Neurol & Psychiat Res & Drug Discovery, Shanghai, Peoples R China; 6.Chinese Acad Sci, Shanghai Inst Mat Med, Analyt Res Ctr Organ & Biol Mol, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhou, Chen,Zhang, Jingjing,Luo, Xinwen,et al. Sodium Oligomannate Electrostatically Binds to Aβ and Blocks Its Aggregation[J]. JOURNAL OF PHYSICAL CHEMISTRY B,2023. |
| APA | Zhou, Chen.,Zhang, Jingjing.,Luo, Xinwen.,Lian, Fulin.,Zeng, Yangyang.,...&Zhang, Naixia.(2023).Sodium Oligomannate Electrostatically Binds to Aβ and Blocks Its Aggregation.JOURNAL OF PHYSICAL CHEMISTRY B. |
| MLA | Zhou, Chen,et al."Sodium Oligomannate Electrostatically Binds to Aβ and Blocks Its Aggregation".JOURNAL OF PHYSICAL CHEMISTRY B (2023). |
入库方式： OAI收割
来源：上海药物研究所
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