LBP1C-2 from Lycium barbarum alleviated age-related bone loss by targeting BMPRIA/BMPRII/Noggin
文献类型：期刊论文
| 作者 | Sun, Chuanxin5; Chen, Xia4; Yang, Shangpo5; Jin, Can4; Ding, Kan1,3,4 ; Chen, Chang2,3,5
|
| 刊名 | CARBOHYDRATE POLYMERS
 |
| 出版日期 | 2023-06-15 |
| 卷号 | 310页码:120725 |
| 关键词 | Lycium barbarum ( L barbarum ) Polysaccharide LBP1C-2 Aging Bone loss BMP signaling |
| DOI | 10.1016/j.carbpol.2023.120725 |
| 文献子类 | Article |
| 英文摘要 | Age-related bone loss is unavoidable and effective safe drugs are in great need. The fruit of Lycium barbarum was recorded to strengthen bones in the Ben Cao Gang Mu (Compendium of Materia Medica). However, there lacks scientific explanation. Herein, we investigated L. barbarum water extract (LBE), L. barbarum polysaccharides (LBP) and the homogeneous polysaccharide LBP1C-2 on the bone loss in adult mouse, aging mouse and ovariectomized mouse models. LBE, LBP and LBP1C-2 all markedly increased bone mass and bone strength in these models and promoted osteoblast proliferation, differentiation and ossification. Mechanistic studies showed that LBP1C-2 binds directly to the BMP receptors (BMPRIA and BMPRII) and noggin, activates the phosphorylation of Smad and disrupts the interaction between noggin and BMPs. Our results clearly elucidate the mechanism, the critical component and the direct targets of L. barbarum and provide potentially safe natural products and new drug candidate against age-related bone loss. |
| WOS关键词 | FRUITS ; L. |
| WOS研究方向 | Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000948946000001 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309689]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Ding, Kan; Chen, Chang |
| 作者单位 | 1.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Guangdong, Peoples R China 2.Beijing Inst Brain Disorders, Beijing 100069, Peoples R China; 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, State Key Lab Drug Res, Shanghai, Peoples R China; 5.Chinese Acad Sci, Inst Biophys, Natl Lab Biomacromol, Beijing 100101, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Sun, Chuanxin,Chen, Xia,Yang, Shangpo,et al. LBP1C-2 from Lycium barbarum alleviated age-related bone loss by targeting BMPRIA/BMPRII/Noggin[J]. CARBOHYDRATE POLYMERS,2023,310:120725. |
| APA | Sun, Chuanxin,Chen, Xia,Yang, Shangpo,Jin, Can,Ding, Kan,&Chen, Chang.(2023).LBP1C-2 from Lycium barbarum alleviated age-related bone loss by targeting BMPRIA/BMPRII/Noggin.CARBOHYDRATE POLYMERS,310,120725. |
| MLA | Sun, Chuanxin,et al."LBP1C-2 from Lycium barbarum alleviated age-related bone loss by targeting BMPRIA/BMPRII/Noggin".CARBOHYDRATE POLYMERS 310(2023):120725. |
入库方式： OAI收割
来源：上海药物研究所
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