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Drug-Free Biomimetic Oxygen Supply Nanovehicle Promotes Ischemia-Reperfusion Therapy in Stroke

文献类型：期刊论文

作者He, Wenxiu4,5; Zhang, Xiao-Yong3; Gong, Xiang2; Luo, Kuankuan5; Mao, Xuening1; Lu, Enhao5; Chen, Yiting5; Wang, Rui5; Zhang, Zhiwen5; Zhao, Jing1
刊名ADVANCED FUNCTIONAL MATERIALS
出版日期2023-05-01
卷号33期号:21
关键词BBB protection drug-free biomimetic nanovehicles hypoxia relief ischemia-reperfusion therapy ischemic strokes
DOI10.1002/adfm.202212919
文献子类Article
英文摘要Recanalization intervention is the primary recommended therapy for ischemic stroke, but the rapid progression of brain damage results in a very narrow time window for ischemia-reperfusion therapy, which remains the biggest obstacle for ischemic stroke treatment. Herein, a drug-free biomimetic nanovehicle capable of improving cerebral ischemic tolerance and thus promoting ischemia-reperfusion therapy is reported. The nanovehicle comprises an amphiphilic polyfluorocarbon, which delivers oxygen to alleviate the hostile hypoxic environment of ischemic brain, and Pluronic P123, which inhibits matrix metalloproteinase-9 to protect the blood-brain barrier (BBB). When intravenously injected into ischemic stroke rats with transient middle cerebral artery occlusion, these nanovehicles are able to preferentially access cerebral ischemic lesions in an inflammation-directed manner, conferring robust ischemic tolerance and reperfusion resistance of brain tissues for ischemia-reperfusion therapy. Furthermore, it is also demonstrated that the nanovehicle is beneficial for mice with permanent ischemic stroke induced by photothrombosis. This work suggests a promising strategy with hypoxia relief and BBB protection for ischemic stroke therapy.
WOS关键词BRAIN ; MATRIX-METALLOPROTEINASE-9 ; NANOPARTICLES ; INHIBITION ; OUTCOMES ; INJURY ; MICE
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种英语
WOS记录号WOS:000939448700001
出版者WILEY-V C H VERLAG GMBH
源URL[http://119.78.100.183/handle/2S10ELR8/309690]  
专题新药研究国家重点实验室
通讯作者Zhang, Zhiwen; Zhao, Jing; Sha, Xianyi
作者单位1.Fudan Univ, Minhang Hosp, Dept Neurol, Shanghai 201102, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res & Ctr Pharmaceut, Shanghai 201203, Peoples R China;
3.Fudan Univ, Key Lab Computat Neurosci & Brain Inspired Intelli, Minist Educ, Shanghai 200433, Peoples R China;
4.Shandong Univ, Cheeloo Coll Med, Sch Pharmaceut Sci, NMPA Key Lab Technol Res & Evaluat Drug Prod,Key L, Jinan 250012, Peoples R China;
5.Fudan Univ, Minhang Hosp, Inst Integrat Med, Sch Pharm,Dept Pharmaceut,Minist Educ,Key Lab Smar, Shanghai 201203, Peoples R China;
推荐引用方式
GB/T 7714		 He, Wenxiu,Zhang, Xiao-Yong,Gong, Xiang,et al. Drug-Free Biomimetic Oxygen Supply Nanovehicle Promotes Ischemia-Reperfusion Therapy in Stroke[J]. ADVANCED FUNCTIONAL MATERIALS,2023,33(21).
APA He, Wenxiu.,Zhang, Xiao-Yong.,Gong, Xiang.,Luo, Kuankuan.,Mao, Xuening.,...&Sha, Xianyi.(2023).Drug-Free Biomimetic Oxygen Supply Nanovehicle Promotes Ischemia-Reperfusion Therapy in Stroke.ADVANCED FUNCTIONAL MATERIALS,33(21).
MLA He, Wenxiu,et al."Drug-Free Biomimetic Oxygen Supply Nanovehicle Promotes Ischemia-Reperfusion Therapy in Stroke".ADVANCED FUNCTIONAL MATERIALS 33.21(2023).

入库方式： OAI收割

来源：上海药物研究所

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