Sarglamides A-E, Indolidinoid-Monoterpenoid Hybrids with Anti- neuroinflammatory Activity from a Sarcandra Species
文献类型：期刊论文
| 作者 | Zhou, Bin1,2; Gong, Qi2; Fu, Yan2; Zhou, Jun-Su2; Zhang, Hai-Yan2 ; Yue, Jian-Min1,2
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| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2023-02-24 |
| DOI | 10.1021/acs.orglett.3c00196 |
| 文献子类 | Article |
| 英文摘要 | Sarglamides A-E (1-5), representing the first example of heterodimers of a trans-N-cinnamoylindolidinoid and alpha-phelladrene derivatives, were isolated from Sarcandra glabra subsp. brachystachys. Particularly, compounds 4 and 5 possess unprecedented cagelike 6/6/5/6/5-and 6/6/6/6/5-fused pentacyclic scaffolds, respectively. Their structures were established by spectroscopic analysis, X-ray crystallography, quantum-chemical calculations, and chemical conversions. Plausible biosynthetic pathways of 1-5 involving the coisolated enantiomers 6a and 6b were proposed. Compounds 3-7 showed inhibitory activity against lipopolysaccharide-induced inflammation in BV-2 microglial cells. |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000937876600001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309691]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Yue, Jian-Min |
| 作者单位 | 1.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhou, Bin,Gong, Qi,Fu, Yan,et al. Sarglamides A-E, Indolidinoid-Monoterpenoid Hybrids with Anti- neuroinflammatory Activity from a Sarcandra Species[J]. ORGANIC LETTERS,2023. |
| APA | Zhou, Bin,Gong, Qi,Fu, Yan,Zhou, Jun-Su,Zhang, Hai-Yan,&Yue, Jian-Min.(2023).Sarglamides A-E, Indolidinoid-Monoterpenoid Hybrids with Anti- neuroinflammatory Activity from a Sarcandra Species.ORGANIC LETTERS. |
| MLA | Zhou, Bin,et al."Sarglamides A-E, Indolidinoid-Monoterpenoid Hybrids with Anti- neuroinflammatory Activity from a Sarcandra Species".ORGANIC LETTERS (2023). |
入库方式： OAI收割
来源：上海药物研究所
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