Two new compounds from the Hainan Soft Corals Sinularia tumulosa and Sinularia depressa with their anti-inflammatory or cytotoxic activities
文献类型：期刊论文
| 作者 | Xu, Ting3,4; Yu, Dan-Dan5; Su, Ming-Zhi5; Yao, Li-Gong4; Li, Song-Wei2; Guo, Yue-Wei1,3,4,5
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| 刊名 | JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
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| 出版日期 | 2023-10-03 |
| 卷号 | 25期号:10页码:949-956 |
| 关键词 | Sinularia marine natural product anti-inflammatory activity cytotoxicity |
| DOI | 10.1080/10286020.2023.2181164 |
| 文献子类 | Article |
| 英文摘要 | The detailed chemical investigations of the South China Sea soft corals Sinularia tumulosa and Sinularia depressa, yielded two new compounds, namely tumulosterol A (1) and 11'-hydroxy-alpha-tocopherylquinone (3), along with four related known ones (2, 5-7). Their structures were determined by extensive spectroscopic analysis and comparison with the spectral data previously reported in the literature. In bioassays, compound 1 displayed significant cytotoxic effects against H1975 and MDA-MB-231 cells with IC50 values of 6.0 and 6.3 mu M, respectively. In addition, compound 3 exhibited interesting inhibitory effect on lipopolysaccharide (LPS)-induced inflammatory responses in RAW264.7 cells with IC50 value of 9.5 mu M. |
| WOS关键词 | POLYHYDROXYLATED STEROIDS ; NATURAL-PRODUCTS ; DITERPENOIDS ; SARCOPHYTON ; METABOLITES ; DERIVATIVES ; TERPENOIDS |
| WOS研究方向 | Plant Sciences ; Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000935210000001 |
| 出版者 | TAYLOR & FRANCIS LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309693]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Li, Song-Wei; Guo, Yue-Wei |
| 作者单位 | 1.Pilot Natl Lab Marine Sci & Technol Qingdao, Open Studio Druggabil Res Marine Nat Prod, Qingdao 266237, Peoples R China 2.Zhejiang Univ Technol, Coll Pharmaceut Sci, Collaborat Innovat Ctr Yangtze River Delta Reg Gre, Hangzhou 310014, Peoples R China; 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 5.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Xu, Ting,Yu, Dan-Dan,Su, Ming-Zhi,et al. Two new compounds from the Hainan Soft Corals Sinularia tumulosa and Sinularia depressa with their anti-inflammatory or cytotoxic activities[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2023,25(10):949-956. |
| APA | Xu, Ting,Yu, Dan-Dan,Su, Ming-Zhi,Yao, Li-Gong,Li, Song-Wei,&Guo, Yue-Wei.(2023).Two new compounds from the Hainan Soft Corals Sinularia tumulosa and Sinularia depressa with their anti-inflammatory or cytotoxic activities.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,25(10),949-956. |
| MLA | Xu, Ting,et al."Two new compounds from the Hainan Soft Corals Sinularia tumulosa and Sinularia depressa with their anti-inflammatory or cytotoxic activities".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 25.10(2023):949-956. |
入库方式： OAI收割
来源：上海药物研究所
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