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A structure defined pectin SA02B from Semiaquilegia adoxoides is metabolized by human gut microbes

文献类型：期刊论文

作者Li, Saijuan1,2,4; Li, Tingting2,3; Wang, Binqiang2,3; Wen, Chang2,3; Li, Meixia2; Ding, Kan2,3,4
刊名INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
出版日期2023-04-15
卷号234页码:123673
关键词Semiaquilegia adoxoides Polysaccharide Pectin Human gut microbiota Degradation Short chain fatty acids
DOI10.1016/j.ijbiomac.2023.123673
文献子类Article
英文摘要Polysaccharide is one of the major factors for shaping the gut microbiota. However, bioactivity of polysaccharide isolated from Semiaquilegia adoxoides on human gut microbiota remains unclear. Thus, we hypothesize gut mi-crobes may act on it. Herein, pectin SA02B from the roots of Semiaquilegia adoxoides with molecular weight 69.26 kDa was elucidated. The backbone of SA02B was composed of alternate 1, 2-linked alpha-Rhap and 1, 4-linked alpha-GalpA, with branches of terminal (T)-, 1, 4-, 1, 3-and 1, 3, 6-linked beta-Galp, T-, 1, 5-and 1, 3, 5-linked alpha-Araf and T-, 1, 4-linked-beta-Xylp substituted at C-4 of 1, 2, 4-linked alpha-Rhap. Bioactivity screening showed SA02B promoted the growth of Bacteroides spp. which deconstructed it into monosaccharide. Simultaneously, we observed competition might exist between Bacteroides spp. and probiotics. Besides, we found that both Bacter-oides spp. and probiotics could generate SCFAs grown on SA02B. Our findings highlight SA02B may deserve as a prebiotic to be explored to benefit the health gut microbiota.
WOS关键词CHAIN FATTY-ACIDS ; POLYSACCHARIDE ; BIOACTIVITY ; ARABINOGALACTAN ; ELUCIDATION ; EVOLUTION ; FEATURES ; EXTRACT ; LEAVES ; FRUITS
WOS研究方向Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
语种英语
WOS记录号WOS:000954876600001
出版者ELSEVIER
源URL[http://119.78.100.183/handle/2S10ELR8/309697]  
专题新药研究国家重点实验室
通讯作者Li, Meixia; Ding, Kan
作者单位1.Zunyi Med Univ, Kweichow Maotai Hosp, Zhongshu Cent St, Zunyi 564500, Renhuai, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, State Key Lab Drug Res,Glycochem & Glycobiol Lab, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China;
3.Zunyi Med Univ, Sch Pharm, 201 Dalian Rd, Zunyi 563003, Peoples R China;
4.Nanjing Univ Chinese Med, Sch Chinese Mat Med, 138 Xianlin Ave, Nanjing 210023, Peoples R China;
推荐引用方式
GB/T 7714		 Li, Saijuan,Li, Tingting,Wang, Binqiang,et al. A structure defined pectin SA02B from Semiaquilegia adoxoides is metabolized by human gut microbes[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2023,234:123673.
APA Li, Saijuan,Li, Tingting,Wang, Binqiang,Wen, Chang,Li, Meixia,&Ding, Kan.(2023).A structure defined pectin SA02B from Semiaquilegia adoxoides is metabolized by human gut microbes.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,234,123673.
MLA Li, Saijuan,et al."A structure defined pectin SA02B from Semiaquilegia adoxoides is metabolized by human gut microbes".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 234(2023):123673.

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来源：上海药物研究所

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