Design of a Coumarin-Based Fluorescent Probe for Efficient In Vivo Imaging of Amyloid-? Plaques
文献类型：期刊论文
| 作者 | Cao, Yangyang4,5; Liu, Xiaohui2,3; Zhang, Jingjing3; Liu, Zhongmin4,5; Fu, Yan3; Zhang, Dong3; Zheng, Mingyue2,3 ; Zhang, Haiyan2,3; Xu, Ming-Hua1,4,5
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| 刊名 | ACS CHEMICAL NEUROSCIENCE
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| 出版日期 | 2023-02-07 |
| 关键词 | Alzheimer?s disease fluorescent probe imaging agent Amyloid-? coumarin |
| DOI | 10.1021/acschemneuro.2c00468 |
| 文献子类 | Article |
| 英文摘要 | Amyloid-beta (A beta) is the core constituent protein of senile plaques, which is one of the key pathological hallmarks of Alzheimer's disease (AD). Here we describe the design, synthesis, and evaluation of coumarin-derived small molecule fluorophores for A beta imaging. By embedding the aromatic coumarin framework into pi bridge of a push-pull chromophore, a novel fluorescence probe XCYC-3 applicable to efficient A beta recognition was discovered. XCYC-3 displays higher fluorescent enhancement for aggregated A beta than monomeric A beta, and possesses good blood-brain barrier permeability. In vitro staining and in vivo imaging studies demonstrated that XCYC-3 could efficiently recognize A beta plaques in the brain of AD transgenic mice. These results suggest that XCYC-3 is a promising fluorescence imaging agent for A beta, which might provide important clues for the future development of potent NIR fluorescent probes for A beta diagnosis. |
| WOS关键词 | ALZHEIMERS-DISEASE ; CROSS-LINKING ; BETA ; PROTEIN ; BRAIN |
| WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000928933400001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309703]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zheng, Mingyue; Zhang, Haiyan; Xu, Ming-Hua |
| 作者单位 | 1.Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Henan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 4.Southern Univ Sci & Technol, Dept Chem, Shenzhen Key Lab Small Mol Drug Discovery & Synth, Guangdong Prov Key Lab Catalysis, Shenzhen 518055, Peoples R China; 5.Southern Univ Sci & Technol, Shenzhen Grubbs Inst, Shenzhen 518055, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Cao, Yangyang,Liu, Xiaohui,Zhang, Jingjing,et al. Design of a Coumarin-Based Fluorescent Probe for Efficient In Vivo Imaging of Amyloid-? Plaques[J]. ACS CHEMICAL NEUROSCIENCE,2023. |
| APA | Cao, Yangyang.,Liu, Xiaohui.,Zhang, Jingjing.,Liu, Zhongmin.,Fu, Yan.,...&Xu, Ming-Hua.(2023).Design of a Coumarin-Based Fluorescent Probe for Efficient In Vivo Imaging of Amyloid-? Plaques.ACS CHEMICAL NEUROSCIENCE. |
| MLA | Cao, Yangyang,et al."Design of a Coumarin-Based Fluorescent Probe for Efficient In Vivo Imaging of Amyloid-? Plaques".ACS CHEMICAL NEUROSCIENCE (2023). |
入库方式： OAI收割
来源：上海药物研究所
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