PRMT6 promotes tumorigenicity and cisplatin response of lung cancer through triggering 6PGD/ENO1 mediated cell metabolism
文献类型:期刊论文
作者 | Sun, Mingming12; Li, Leilei11; Niu, Yujia10; Wang, Yingzhi12; Yan, Qi12; Xie, Fei12; Qiao, Yaya12; Song, Jiaqi12; Sun, Huanran12; Li, Zhen11 |
刊名 | ACTA PHARMACEUTICA SINICA B |
出版日期 | 2023 |
卷号 | 13期号:1页码:157-173 |
关键词 | Lung cancer Metabolic reprogramming Post-translational modification PRMT6 Pentose phosphate pathway flux Glycolysis 6-Phospho-gluconate dehydrogenase a-enolase ENO1 |
DOI | 10.1016/j.apsb.2022.05.019 |
文献子类 | Article |
英文摘要 | Metabolic reprogramming is a hallmark of cancer, including lung cancer. However, the exact underlying mechanism and therapeutic potential are largely unknown. Here we report that protein argi-nine methyltransferase 6 (PRMT6) is highly expressed in lung cancer and is required for cell metabolism, tumorigenicity, and cisplatin response of lung cancer. PRMT6 regulated the oxidative pentose phosphate pathway (PPP) flux and glycolysis pathway in human lung cancer by increasing the activity of 6-phospho-gluconate dehydrogenase (6PGD) and a-enolase (ENO1). Furthermore, PRMT6 methylated R324 of 6PGD to enhancing its activity; while methylation at R9 and R372 of ENO1 promotes formation of active ENO1 dimers and 2-phosphoglycerate (2-PG) binding to ENO1, respectively. Lastly, targeting PRMT6 blocked the oxidative PPP flux, glycolysis pathway, and tumor growth, as well as enhanced the anti-tumor effects of cisplatin in lung cancer. Together, this study demonstrates that PRMT6 acts as a post -translational modification (PTM) regulator of glucose metabolism, which leads to the pathogenesis of lung cancer. It was proven that the PRMT6-6PGD/ENO1 regulatory axis is an important determinant of carcinogenesis and may become a promising cancer therapeutic strategy.(c) 2023 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
WOS关键词 | ARGININE METHYLTRANSFERASES ; DYSREGULATION ; METHYLATION |
WOS研究方向 | Pharmacology & Pharmacy |
语种 | 英语 |
出版者 | INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES |
WOS记录号 | WOS:000935111000001 |
源URL | [http://119.78.100.183/handle/2S10ELR8/309705] |
专题 | 新药研究国家重点实验室 |
通讯作者 | Lin, Shu-Hai; Luo, Cheng; Zhang, Shuai; Shan, Changliang |
作者单位 | 1.Nankai Univ, Tianjin Union Med Ctr, Dept Colorectal Surg, Tianjin 300121, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 3.Xi An Jiao Tong Univ, Affiliated Hosp 2, Natl Local Joint Engn Res Ctr Biodiagnost & Biothe, Xian 710004, Peoples R China; 4.Shandong Normal Univ, Collaborat Innovat Ctr Cell Biol Univ Shandong, Inst Biomed Sci, Coll Life Sci,Shandong Prov Key Lab Anim Resistanc, Jinan 250014, Peoples R China; 5.Wenzhou Med Univ, Sch Lab Med & Life Sci, Wenzhou 325035, Peoples R China; 6.Univ South China, Sch Basic Med Sci, Hengyang Med Sch, Dept Biochem & Mol Biol, Hengyang 421001, Peoples R China; 7.Dalian Univ, Med Sch, Dept Pathol, Dalian 116622, Peoples R China; 8.Jining Med Univ, Inst Precis Med, Dept Pathol, Jining 272067, Peoples R China; 9.Tianjin Univ Tradit Chinese Med, Sch Integrat Med, Tianjin 301617, Peoples R China; 10.Xiamen Univ, Innovat Ctr Cell Signaling Network, Sch Life Sci, State Key Lab Cellular Stress Biol, Xiamen 361102, Peoples R China; |
推荐引用方式 GB/T 7714 | Sun, Mingming,Li, Leilei,Niu, Yujia,et al. PRMT6 promotes tumorigenicity and cisplatin response of lung cancer through triggering 6PGD/ENO1 mediated cell metabolism[J]. ACTA PHARMACEUTICA SINICA B,2023,13(1):157-173. |
APA | Sun, Mingming.,Li, Leilei.,Niu, Yujia.,Wang, Yingzhi.,Yan, Qi.,...&Shan, Changliang.(2023).PRMT6 promotes tumorigenicity and cisplatin response of lung cancer through triggering 6PGD/ENO1 mediated cell metabolism.ACTA PHARMACEUTICA SINICA B,13(1),157-173. |
MLA | Sun, Mingming,et al."PRMT6 promotes tumorigenicity and cisplatin response of lung cancer through triggering 6PGD/ENO1 mediated cell metabolism".ACTA PHARMACEUTICA SINICA B 13.1(2023):157-173. |
入库方式: OAI收割
来源:上海药物研究所
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