Rhodium(I)-Catalyzed Direct Enantioselective C-H Functionalization of Indoles
文献类型：期刊论文
| 作者 | Zhu, Dong-Xing4; Xu, Ming-Hua1,2,3 |
| 刊名 | JOURNAL OF ORGANIC CHEMISTRY
 |
| 出版日期 | 2023-02-01 |
| 卷号 | 88期号:12页码:7844-7848 |
| DOI | 10.1021/acs.joc.2c02624 |
| 文献子类 | Article |
| 英文摘要 | A highly regiospecific vinylogous carbene insertion protocol for direct asymmetric C-H functionalization of indoles with arylvinyldiazoacetates has been developed. Under the catalysis of simple Rh(I)/chiral diene complexes, the reaction occurs solely at the vinylogous position of the vinylcarbenoid with exceptional E selectivity and enantiocontrol. It provides an efficient way to obtain an interesting class of chiral indole scaffolds bearing an alpha,beta-unsaturated ester unit and a gem-diaryl carbon stereocenter in good yields (<99%) with excellent enantioselectivities (<96%) at room temperature. |
| WOS关键词 | CATALYZED ASYMMETRIC REACTIONS ; CARBENE INSERTION ; PYRROLES ; LIGANDS ; CARBOXYLATES ; STRATEGIES ; ACCESS ; BONDS ; ACIDS |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000960615000001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309707]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Xu, Ming-Hua |
| 作者单位 | 1.Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Henan, Peoples R China 2.Southern Univ Sci & Technol, Dept Chem, Shenzhen 518055, Peoples R China; 3.Southern Univ Sci & Technol, Shenzhen Grubbs Inst, Shenzhen 518055, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhu, Dong-Xing,Xu, Ming-Hua. Rhodium(I)-Catalyzed Direct Enantioselective C-H Functionalization of Indoles[J]. JOURNAL OF ORGANIC CHEMISTRY,2023,88(12):7844-7848. |
| APA | Zhu, Dong-Xing,&Xu, Ming-Hua.(2023).Rhodium(I)-Catalyzed Direct Enantioselective C-H Functionalization of Indoles.JOURNAL OF ORGANIC CHEMISTRY,88(12),7844-7848. |
| MLA | Zhu, Dong-Xing,et al."Rhodium(I)-Catalyzed Direct Enantioselective C-H Functionalization of Indoles".JOURNAL OF ORGANIC CHEMISTRY 88.12(2023):7844-7848. |
入库方式： OAI收割
来源：上海药物研究所
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