丹参脂溶性成分结构优化研究进展
文献类型：期刊论文
| 作者 | 李兴军2,3; 王江1,3 ; 柳红2,3
|
| 刊名 | CHINESE JOURNAL OF ORGANIC CHEMISTRY
 |
| 出版日期 | 2023-02-01 |
| 卷号 | 43期号:2页码:471-490 |
| 关键词 | Salvia miltiorrhiza lipid-soluble ingredients structural optimization |
| DOI | 10.6023/cjoc202206054 |
| 其他题名 | Research Progress on Structural Optimization on the Lipid-Soluble Ingredients of Salvia miltiorrhiza |
| 文献子类 | Review |
| 英文摘要 | As a traditional Chinese medicine, Salvia miltiorrhiza has been widely applied in the treatment of cardiovascular diseases in clinical. Research on its active components and derivatives has become an issue of great focus both domestically and internationally. The active ingredients of Salvia miltiorrhiza are mainly divided into lipid-soluble and water-soluble ingredients with the lipid-soluble ones performing various pharmacological properties. However, their poor solubility and bioavailability have limited their clinical applications. In order to promote the clinical application of lipid-soluble ingredients of Salvia miltiorrhiza, these components are used as lead compounds to perform structural optimization to improve drug-like properties. In order to generate novel research ideas for the development of novel drugs based on lipid-soluble ingredients of Salvia miltiorrhiza, the research progress of structural optimization and related biological activities of the major lipid-soluble ingredients of Salvia miltiorrhiza in recent years is reviewed, the structural optimization strategy of the drug-like properties of these compounds and the synthetic approaches of their derivatives are summarized, and the effects of different structure modifications on pharmacological activities are described. |
| WOS关键词 | NEO-TANSHINLACTONE ; BIOLOGICAL EVALUATION ; HERBAL MEDICINE ; TANSHINONE IIA ; DERIVATIVES ; DNA ; DANSHEN ; DESIGN ; CELL |
| WOS研究方向 | Chemistry |
| 语种 | 中文 |
| WOS记录号 | WOS:000940602100006 |
| 出版者 | SCIENCE PRESS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309708]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | 柳红 |
| 作者单位 | 1.Lingang Lab, Shanghai 200031, Peoples R China 2.China Pharmaceut Univ, Sch Pharm, Nanjing 211198, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | 李兴军,王江,柳红. 丹参脂溶性成分结构优化研究进展[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2023,43(2):471-490. |
| APA | 李兴军,王江,&柳红.(2023).丹参脂溶性成分结构优化研究进展.CHINESE JOURNAL OF ORGANIC CHEMISTRY,43(2),471-490. |
| MLA | 李兴军,et al."丹参脂溶性成分结构优化研究进展".CHINESE JOURNAL OF ORGANIC CHEMISTRY 43.2(2023):471-490. |
入库方式： OAI收割
来源：上海药物研究所
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