Cembrane Diterpenes Possessing Nonaromatic Oxacycles from the Hainan Soft Coral Sarcophyton mililatensis
文献类型：期刊论文
| 作者 | Zhang, Ling6; Yang, Min5; Chen, Zi-Hui5; Ge, Zeng-Yue6; Li, Song-Wei5; Yan, Xian-Yun6; Yao, Li-Gong5; Liang, Lin-Fu6; Guo, Yue-Wei1,2,3,4,5
|
| 刊名 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
 |
| 出版日期 | 2023-02-01 |
| 卷号 | 24期号:3页码:1979 |
| 关键词 | soft coral Sarcophyton mililatensis cembrane diterpene absolute configuration TNF-alpha inhibitory binding mode |
| DOI | 10.3390/ijms24031979 |
| 文献子类 | Article |
| 英文摘要 | Documents on the chemical composition of the soft coral Sarcophyton mililatensis are sparse. The present investigation of the Hainan soft coral S. mililatensis resulted in the discovery of six new cembrane diterpenes, sarcoxacyclols A-F (1-6) and four known analogs (7-10). Their structures were elucidated by extensive spectroscopic analysis along with a comparison with the data in current literature. The nonaromatic oxacycles in their structures were the rarely found tetrahydrofuran ether across C-1 and C-12 and tetrahydropyran ether across C-1 and C-11, respectively. Moreover, the absolute configuration of compound 4 was established unambiguously by X-ray diffraction analysis using Ga K alpha radiation (lambda = 1.34139 angstrom). Based on the biogenetical consideration, the absolute configurations of other five new compounds were tentatively assumed. Assessment of the bioactivity for these secondary metabolites revealed that compound 1 exhibited significant tumor necrosis factor (TNF)-alpha inhibitory activity (IC50 = 9.5 mu mol/L), similar to the positive control dexamethasone (IC50 = 8.7 mu mol/L), but no obvious cytotoxicity towards RAW264.7 cells (CC50 > 50 mu mol/L). The preliminary molecular docking suggested the crucial roles of the hydroxyl and acetoxyl groups in the computational prediction of the binding mode between the diterpene and the protein. |
| WOS关键词 | BISCEMBRANOIDS |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000932927900001 |
| 出版者 | MDPI |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309712]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Liang, Lin-Fu; Guo, Yue-Wei |
| 作者单位 | 1.Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Peoples R China 2.Zhejiang Univ Technol, Collaborat Innovat Ctr Yangtze River Delta Reg Gre, Hangzhou 310014, Peoples R China; 3.Pilot Natl Lab Marine Sci & Technol Qingdao, Open Studio Druggabil Res Marine Nat Prod, 1 Wenhai Rd, Qingdao 266237, Peoples R China; 4.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Peoples R China; 5.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd, Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China; 6.Cent South Univ Forestry & Technol, Coll Mat Sci & Engn, Changsha 410004, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhang, Ling,Yang, Min,Chen, Zi-Hui,et al. Cembrane Diterpenes Possessing Nonaromatic Oxacycles from the Hainan Soft Coral Sarcophyton mililatensis[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2023,24(3):1979. |
| APA | Zhang, Ling.,Yang, Min.,Chen, Zi-Hui.,Ge, Zeng-Yue.,Li, Song-Wei.,...&Guo, Yue-Wei.(2023).Cembrane Diterpenes Possessing Nonaromatic Oxacycles from the Hainan Soft Coral Sarcophyton mililatensis.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,24(3),1979. |
| MLA | Zhang, Ling,et al."Cembrane Diterpenes Possessing Nonaromatic Oxacycles from the Hainan Soft Coral Sarcophyton mililatensis".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 24.3(2023):1979. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。