Objective To observe the different brain activation of acupuncture and electroacupuncture on heroin addicts and healthy subjects. Methods Tbe different brain activation involved in heroin addiction between healthy subjects and addicts was detected by fMRI. Acupuncture point used in present study was Zusanli （ST 36）. Results Different brain activations between healthy subjects and addicts during electroacupuncture were hypothalamus （ X0, Y2, Z9, t = 7.36, P 〈 0.01 ）, anterior cingulate （ X5, Y49, Z8, t = 4.11, P 〈 0.01 ）, temporal gyms（ X61, Y I 2, Z8, t = 3.05, P 〈 0.01 ）. The difference of activated regions during conventional acupuncture between healthy subjects and heroin addicts was thalamus （ X2, Y16, Z12, t = 2.87, P 〈 0.01 ） , parahippocampus （X17,Y52,Z3,t=3.14, P〈0.01）,and hypothalamus（X0,Y2,Z9, t=6.98,P〈0.01）. Conclusion Regions with significant activation detected by fMRI are different during acupuncture in heroin addicts and in the healthy subjects. Notably,the hypothalamus activation is more robust in the addicts than in the healthy subjects during acupuncture stimulation.

目的观察海洛因成瘾者和健康被试接受传统针刺和电针治疗时功能性脑区的激活差异。方法采用功能性核磁共振成像技术，分别对健康被试者和海洛因成瘾病人接受电针以及传统针刺治疗的中枢激活位点进行了比较。针刺穴位取双侧足三里穴。结果健康被试和海洛因成瘾者电针激活的脑区差异主要集中在下丘脑（横断面0、冠状面2、矢状面9，t=7．36，P〈0．01）、前额扣带（横断面5、冠状面49、矢状面8，t：4．11，P〈0．01）和颞叶（横断面61、冠状面12、矢状面8，t=3．05，P〈0．01）。健康被试和海洛因成瘾病人接受传统针刺时激活差别主要集中在下丘脑（横断面0、冠状面2、矢状面9，t=6．98，P〈0．001）、海马旁回（横断面17、冠状面52、矢状面3，t=3．14，P〈0．01）和丘脑（横断面2、冠状面16、矢状面12，t=2．87，P〈0．01）。结论海洛因成瘾者和健康被试电针刺激的中枢激活脑区有差异，特别是海洛因成瘾患者下丘脑激活明显增强。

国家重点基础研究发展规划项目（973计划）（2009CB52208）,浙江省重大项目（D2080515）