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Epistasis in neurotransmitter receptors linked to posttraumatic stress disorder and major depressive disorder comorbidity in traumatized Chinese

文献类型：期刊论文

作者Xu, Ling3,4,5; Zhang, Jingyi3,4,5; Yang, Haibo2; Cao, Chengqi3,4,5; Fang, Ruojiao3,4,5; Liu, Ping1; Luo, Shu1; Wang, Binbin3,4,5; Zhang, Kunlin3,4,5; Wang, Li3,4,5
刊名FRONTIERS IN PSYCHIATRY
出版日期2024-02-29
卷号15页码:10
关键词PTSD-MDD comorbidity gene x gene interaction single nucleotide polymorphism neuropeptide Y dopamine
ISSN号1664-0640
DOI10.3389/fpsyt.2024.1257911
通讯作者Zhang, Kunlin(zhangkl@psych.ac.cn) ; Wang, Li(wangli1@psych.ac.cn)
英文摘要Background Posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) comorbidity occurs through exposure to trauma with genetic susceptibility. Neuropeptide-Y (NPY) and dopamine are neurotransmitters associated with anxiety and stress-related psychiatry through receptors. We attempted to explore the genetic association between two neurotransmitter receptor systems and the PTSD-MDD comorbidity.Methods Four groups were identified using latent profile analysis (LPA) to examine the patterns of PTSD and MDD comorbidity among survivors exposed to earthquake-related trauma: low symptoms, predominantly depression, predominantly PTSD, and PTSD-MDD comorbidity. NPY2R (rs4425326), NPY5R (rs11724320), DRD2 (rs1079597), and DRD3 (rs6280) were genotyped from 1,140 Chinese participants exposed to earthquake-related trauma. Main, gene-environment interaction (G x E), and gene-gene interaction (G x G) effects for low symptoms, predominantly depression, and predominantly PTSD were tested using a multinomial logistic model with PTSD-MDD comorbidity as a reference.Results The results demonstrated that compared to PTSD-MDD comorbidity, epistasis (G x G) NPY2R-DRD2 (rs4425326 x rs1079597) affects low symptoms (beta = -0.66, OR = 0.52 [95% CI: 0.32-0.84], p = 0.008, pperm = 0.008) and predominantly PTSD (beta = -0.56, OR = 0.57 [95% CI: 0.34-0.97], p = 0.037, pperm = 0.039), while NPY2R-DRD3 (rs4425326 x rs6280) impacts low symptoms (beta = 0.82, OR = 2.27 [95% CI: 1.26-4.10], p = 0.006, pperm = 0.005) and predominantly depression (beta = 1.08, R = 2.95 [95% CI: 1.55-5.62], p = 0.001, pperm = 0.001). The two G x G effects are independent.Conclusion NPY and dopamine receptor genes are related to the genetic etiology of PTSD-MDD comorbidity, whose specific mechanisms can be studied at multiple levels.
收录类别SCI
WOS关键词NEUROPEPTIDE-Y ; EPIDEMIOLOGIC SAMPLE ; ALCOHOL DEPENDENCE ; DOPAMINE ; GENE ; ASSOCIATION ; SYMPTOMS ; RISK ; PTSD ; POLYMORPHISM
资助项目National Natural Science Foundation of China10.13039/501100001809
WOS研究方向Psychiatry
语种英语
WOS记录号WOS:001183661000001
出版者FRONTIERS MEDIA SA
资助机构National Natural Science Foundation of China10.13039/501100001809
源URL[http://ir.psych.ac.cn/handle/311026/47335]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Zhang, Kunlin; Wang, Li
作者单位1.Peoples Hosp Deyang City, Deyang, Sichuan, Peoples R China
2.Tianjin Normal Univ, Acad Psychol & Behav, Tianjin, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Ctr Genet & Biomed Informat Res, CAS Key Lab Mental Hlth, Beijing, Peoples R China
5.Chinese Acad Sci, Lab Traumat Stress Studies, CAS Key Lab Mental Hlth, Inst Psychol, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Xu, Ling,Zhang, Jingyi,Yang, Haibo,et al. Epistasis in neurotransmitter receptors linked to posttraumatic stress disorder and major depressive disorder comorbidity in traumatized Chinese[J]. FRONTIERS IN PSYCHIATRY,2024,15:10.
APA Xu, Ling.,Zhang, Jingyi.,Yang, Haibo.,Cao, Chengqi.,Fang, Ruojiao.,...&Wang, Li.(2024).Epistasis in neurotransmitter receptors linked to posttraumatic stress disorder and major depressive disorder comorbidity in traumatized Chinese.FRONTIERS IN PSYCHIATRY,15,10.
MLA Xu, Ling,et al."Epistasis in neurotransmitter receptors linked to posttraumatic stress disorder and major depressive disorder comorbidity in traumatized Chinese".FRONTIERS IN PSYCHIATRY 15(2024):10.

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来源：心理研究所

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