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Gender differences in prevalence and clinical correlates of anxiety in first-episode and drug-na?ve patients with major depressive disorder comorbid with metabolic syndrome

文献类型：期刊论文

作者Gao, Wenqi5; Deng, Zhifang4; Cai, Xiaonan5; Zhang, Dan3; Xiao, Han5; Zhang, Xiangyang1,2
刊名BMC PSYCHIATRY
出版日期2024-02-22
卷号24期号:1页码:8
关键词Metabolic syndrome Anxiety First-episode and drug-naive major depressive disorder Chinese han Gender differences
DOI10.1186/s12888-024-05574-w
通讯作者Xiao, Han(tjxiaohan@hust.edu.cn) ; Zhang, Xiangyang(zhangxy@psych.ac.cn)
英文摘要BackgroundAlthough gender differences in major depressive disorder (MDD) have been widely reported, there has not been much focus on gender differences in comorbidity. In patients with MDD and comorbid metabolic syndrome (Mets), the goal of this study was to investigate potential gender differences in the prevalence and clinical correlates of concomitant anxiety.MethodsSeven hundred and ninety-four first-episode and drug-naive patients (FEDN) patients with MDD and comorbid Mets were recruited. For each patient, sociodemographic data, thyroid function indicators, and Mets parameters were acquired. Each participant completed the 14-item Hamilton Assessment Scale for Anxiety (HAMA) and the 17-item Hamilton Assessment Scale for Depression (HAMD).ResultsThere were no gender differences in the prevalence of anxiety in patients with MDD and comorbid Mets. Female patients with MDD had a shorter duration of illness. Correlation analysis showed that HAMD score, TSH, TgAb, and TPOAb were associated with anxiety prevalence in female patients, whereas anxiety onset in male patients was only associated with TSH, TgAb, and TPOAb levels. In addition, multiple logistic regression analysis showed that TSH and TgAb predicted anxiety in male patients, whereas HAMD score and age of onset significantly predicted anxiety in female patients.LimitationsCross-sectional design and no control for anxiety-related factors.ConclusionsOur study showed no gender differences in the prevalence of anxiety in patients with MDD and comorbid Mets. HAMD score was associated with anxiety in female patients, whereas TSH, TgAb, and TPOAb were associated with anxiety in male patients.
收录类别SCI
WOS关键词MENTAL-HEALTH SURVEY ; ANXIOUS DEPRESSION ; ASSOCIATION ; RISK ; SEX ; SCHIZOPHRENIA ; METAANALYSIS ; POPULATION ; DEFINITION ; SYMPTOMS
资助项目National Natural Science Foundation of China
WOS研究方向Psychiatry
语种英语
出版者BMC
WOS记录号WOS:001172694800004
资助机构National Natural Science Foundation of China
源URL[http://ir.psych.ac.cn/handle/311026/47344]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Xiao, Han; Zhang, Xiangyang
作者单位1.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
2.Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
3.Huazhong Univ & Technol, Wuhan Childrens Hosp, Wuhan Maternal & Child Healthcare Hosp, Tongji Med Coll,Woman Dept Community, Wuhan 430015, Hubei, Peoples R China
4.Huazhong Univ Sci & Technol, Cent Hosp Wuhan, Tongji Med Coll, Dept Pharm, Wuhan 430030, Peoples R China
5.Huazhong Univ & Technol, Wuhan Childrens Hosp, Wuhan Maternal & Child Healthcare Hosp, Inst Maternal & Child Hlth, Wuhan 430015, Hubei, Peoples R China
推荐引用方式
GB/T 7714		 Gao, Wenqi,Deng, Zhifang,Cai, Xiaonan,et al. Gender differences in prevalence and clinical correlates of anxiety in first-episode and drug-na?ve patients with major depressive disorder comorbid with metabolic syndrome[J]. BMC PSYCHIATRY,2024,24(1):8.
APA Gao, Wenqi,Deng, Zhifang,Cai, Xiaonan,Zhang, Dan,Xiao, Han,&Zhang, Xiangyang.(2024).Gender differences in prevalence and clinical correlates of anxiety in first-episode and drug-na?ve patients with major depressive disorder comorbid with metabolic syndrome.BMC PSYCHIATRY,24(1),8.
MLA Gao, Wenqi,et al."Gender differences in prevalence and clinical correlates of anxiety in first-episode and drug-na?ve patients with major depressive disorder comorbid with metabolic syndrome".BMC PSYCHIATRY 24.1(2024):8.

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来源：心理研究所

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