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Association between triglyceride glucose index (TyG) and psychotic symptoms in patients with first-episode drug-na?ve major depressive disorder

文献类型：期刊论文

作者Liu, Junjun3,4,5; Wang, Yangchun4; Mu, Wei2; Liu, Yang4; Tong, Ruixiang4; Lu, Zhaomin4; Yuan, Hsinsung4; Jia, Fengnan3; Zhang, Xiaobin3; Li, Zhe3
刊名FRONTIERS IN PSYCHIATRY
出版日期2024-02-23
卷号15页码:11
关键词major depressive disorder psychotic symptoms triglyceride glucose index insulin resistance type 2 diabetes mellitus
ISSN号1664-0640
DOI10.3389/fpsyt.2024.1342933
通讯作者Du, Xiangdong(xiangdong-du@163.com) ; Zhang, Xiangyang(zhangxy@psych.ac.cn)
英文摘要Objective Major depressive disorder (MDD) sufferers frequently have psychotic symptoms, yet the underlying triggers remain elusive. Prior research suggests a link between insulin resistance (IR) and increased occurrence of psychotic symptoms. Hence, this study sought to investigate the potential association between psychotic symptoms in Chinese patients experiencing their first-episode drug-naive (FEDN) MDD and the triglyceride glucose (TyG) index, an alternative measure of insulin resistance (IR).Methods Between September 2016 and December 2018, 1,718 FEDN MDD patients with an average age of 34.9 +/- 12.4 years were recruited for this cross-sectional study at the First Hospital of Shanxi Medical University in China. The study collected clinical and demographic data and included assessments of anxiety, depression, and psychotic symptoms using the 14-item Hamilton Anxiety Rating Scale (HAMA), the 17-item Hamilton Depression Rating Scale (HAMD-17), and the positive subscales of the Positive and Negative Syndrome Scale (PANSS), respectively. Measurements of metabolic parameters, fasting blood glucose (FBG), and thyroid hormones were also gathered. To assess the correlation between the TyG index and the likelihood of psychotic symptoms, the study used multivariable binary logistic regression analysis. Additionally, two-segmented linear regression models were employed to investigate possible threshold effects in case non-linearity relationships were identified.Results Among the patients, 9.95% (171 out of 1,718) exhibited psychotic symptoms. Multivariable logistic regression analysis showed a positive correlation between the TyG index and the likelihood of psychotic symptoms (OR = 2.12, 95% CI: 1.21-3.74, P = 0.01) after adjusting for confounding variables. Moreover, smoothed plots revealed a nonlinear relationship with the TyG index, revealing an inflection point at 8.42. Interestingly, no significant link was observed to the left of the inflection point (OR = 0.50, 95% CI: 0.04-6.64, P = 0.60), whereas beyond this point, a positive correlation emerged between the TyG index and psychotic symptoms (OR = 2.42, 95% CI: 1.31-4.48, P = 0.01). Particularly, a considerable 142% rise in the probability of experiencing psychotic symptoms was found with each incremental elevation in the TyG index.Conclusions Understanding the non-linear link between the TyG index and the risk of psychotic symptoms in Chinese patients with FEDN MDD highlights the potential for targeted therapeutic approaches. By acknowledging the threshold effect observed, there is an opportunity to mitigate risk factors associated with IR-related psychiatric comorbidities through tailored interventions. These preliminary results stress the need for further longitudinal research to solidify these insights and contribute to more effective therapeutic strategies.
收录类别SCI
WOS关键词INSULIN-RESISTANCE ; DIABETES-MELLITUS ; PREVALENCE ; SEVERITY ; RISK ; FEATURES
资助项目Suzhou Gusu Health Talents Scientific Research Project[GSWS2021053] ; Suzhou Gusu Health Talents Scientific Research Project[GSWS2019070] ; Key Diagnosis and treatment Program of Suzhou[LCZX202016] ; Key Diagnosis and treatment Program of Suzhou[Szlcyxzx202109] ; China Rural Social Survey (Yunnan) ; Medical Science and Technology Development Foundation, Nanjing Department of Health[YKK21216] ; Medical Science and Technology Development Foundation, Nanjing Department of Health[YKK20184] ; Medical Science and Technology Development Foundation, Nanjing Department of Health[YKK22264]
WOS研究方向Psychiatry
语种英语
WOS记录号WOS:001177013200001
出版者FRONTIERS MEDIA SA
资助机构Suzhou Gusu Health Talents Scientific Research Project ; Key Diagnosis and treatment Program of Suzhou ; China Rural Social Survey (Yunnan) ; Medical Science and Technology Development Foundation, Nanjing Department of Health
源URL[http://ir.psych.ac.cn/handle/311026/47347]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Du, Xiangdong; Zhang, Xiangyang
作者单位1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
2.Yunnan Univ, Sch Ethnol & Sociol, Kunming, Peoples R China
3.Soochow Univ, Suzhou Guangji Hosp, Affiliated Guangji Hosp, Suzhou, Peoples R China
4.Nanjing Meishan Hosp, Nanjing, Peoples R China
5.Soochow Univ, Suzhou, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Junjun,Wang, Yangchun,Mu, Wei,et al. Association between triglyceride glucose index (TyG) and psychotic symptoms in patients with first-episode drug-na?ve major depressive disorder[J]. FRONTIERS IN PSYCHIATRY,2024,15:11.
APA Liu, Junjun.,Wang, Yangchun.,Mu, Wei.,Liu, Yang.,Tong, Ruixiang.,...&Zhang, Xiangyang.(2024).Association between triglyceride glucose index (TyG) and psychotic symptoms in patients with first-episode drug-na?ve major depressive disorder.FRONTIERS IN PSYCHIATRY,15,11.
MLA Liu, Junjun,et al."Association between triglyceride glucose index (TyG) and psychotic symptoms in patients with first-episode drug-na?ve major depressive disorder".FRONTIERS IN PSYCHIATRY 15(2024):11.

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