The Born in Guangzhou Cohort Study enables generational genetic discoveries
文献类型：期刊论文
| 作者 | Huang, Shujia11; Liu, Siyang10; Huang, Mingxi11; He, Jian-Rong8,9,11; Wang, Chengrui11; Wang, Tianyi6,7; Feng, Xiaotian6,7; Kuang, Yashu9,11; Lu, Jinhua9,11; Gu, Yuqin10 |
| 刊名 | NATURE
 |
| 出版日期 | 2024-02-15 |
| 卷号 | 626期号:7999页码:565-+ |
| ISSN号 | 0028-0836 |
| DOI | 10.1038/s41586-023-06988-4 |
| 通讯作者 | Xia, Huimin(xia.huimin@bigcs.org) ; Qiu, Xiu(xiu.qiu@bigcs.org) |
| 英文摘要 | Genomic research that targets large-scale, prospective birth cohorts constitutes an essential strategy for understanding the influence of genetics and environment on human health(1). Nonetheless, such studies remain scarce, particularly in Asia. Here we present the phase I genome study of the Born in Guangzhou Cohort Study(2) (BIGCS), which encompasses the sequencing and analysis of 4,053 Chinese individuals, primarily composed of trios or mother-infant duos residing in South China. Our analysis reveals novel genetic variants, a high-quality reference panel, and fine-scale local genetic structure within BIGCS. Notably, we identify previously unreported East Asian-specific genetic associations with maternal total bile acid, gestational weight gain and infant cord blood traits. Additionally, we observe prevalent age-specific genetic effects on lipid levels in mothers and infants. In an exploratory intergenerational Mendelian randomization analysis, we estimate the maternal putatively causal and fetal genetic effects of seven adult phenotypes on seven fetal growth-related measurements. These findings illuminate the genetic links between maternal and early-life traits in an East Asian population and lay the groundwork for future research into the intricate interplay of genetics, intrauterine exposures and early-life experiences in shaping long-term health. |
| WOS关键词 | POPULATION HISTORY ; ADMIXTURE ; BIRTH ; ASIA ; ASSOCIATIONS ; IMPUTATION ; PREGNANCY ; FRAMEWORK ; ANCESTRY ; NORTHERN |
| 资助项目 | Ministry of Science and Technology of the People's Republic of China[2022YFC2702903] ; Ministry of Science and Technology of the People's Republic of China[2022YFC2704601] ; Ministry of Science and Technology of the People's Republic of China[2021ZD0200536] ; National Natural Science Foundation of China[81673181] ; National Natural Science Foundation of China[82173525] ; National Natural Science Foundation of China[31900487] ; National Natural Science Foundation of China[82003471] ; National Natural Science Foundation of China[82273642] ; Guangdong Basic and Applied Basic Research Foundation[2022B1515120080] ; Guangdong Basic and Applied Basic Research Foundation[2020A1515110859] ; Science and Technology Planning Project of Guangdong Province[2019B020227001] ; Science and Technology Planning Project of Guangdong Province[2019B030316014] ; Guangzhou Municipal Science and Technology Bureau[202201020656] ; Guangzhou Municipal Science and Technology Bureau[202102010254] ; Guangzhou Municipal Science and Technology Bureau[202007030002] ; Guangzhou Municipal Health Commission[2023A031001] ; Shenzhen Basic Research Foundation[20220818100717002] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:001163408400005 |
| 出版者 | NATURE PORTFOLIO |
| 资助机构 | Ministry of Science and Technology of the People's Republic of China ; National Natural Science Foundation of China ; Guangdong Basic and Applied Basic Research Foundation ; Science and Technology Planning Project of Guangdong Province ; Guangzhou Municipal Science and Technology Bureau ; Guangzhou Municipal Health Commission ; Shenzhen Basic Research Foundation |
| 源URL | [http://119.78.100.205/handle/311034/23414]  |
| 专题 | 中国科学院古脊椎动物与古人类研究所 |
| 通讯作者 | Xia, Huimin; Qiu, Xiu |
| 作者单位 | 1.Guangzhou Med Univ, Guangzhou Women & Childrens Med Ctr, Dept Pediat Surg, Guangzhou, Peoples R China 2.Guangzhou Med Univ, Guangzhou Women & Childrens Med Ctr, Prov Key Lab Res Struct Birth Defect Dis, Guangzhou, Peoples R China 3.Guangzhou Med Univ, Guangzhou Women & Childrens Med Ctr, Ctr Newborn Care, Guangzhou, Peoples R China 4.Guangzhou Med Univ, Guangzhou Women & Childrens Med Ctr, Div Neonatol, Guangzhou, Peoples R China 5.Guangzhou Med Univ, Dept Womens Hlth, Guangzhou Women & Childrens Med Ctr, Prov Key Clin Specialty Woman & Child Hlth, Guangzhou, Peoples R China 6.Univ Chinese Acad Sci, Beijing, Peoples R China 7.Chinese Acad Sci, Inst Vertebrate Paleontol & Paleoanthropol, Key Lab Vertebrate Evolut & Human Origins, Beijing, Peoples R China 8.Guangzhou Med Univ, Dept Obstet & Gynecol, Guangzhou Women & Childrens Med Ctr, Guangzhou, Peoples R China 9.Prov Clin Res Ctr Child Hlth, Guangzhou, Peoples R China 10.Sun Yat Sen Univ, Sch Publ Hlth Shenzhen, Shenzhen Campus, Shenzhen, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Shujia,Liu, Siyang,Huang, Mingxi,et al. The Born in Guangzhou Cohort Study enables generational genetic discoveries[J]. NATURE,2024,626(7999):565-+. |
| APA | Huang, Shujia.,Liu, Siyang.,Huang, Mingxi.,He, Jian-Rong.,Wang, Chengrui.,...&Qiu, Xiu.(2024).The Born in Guangzhou Cohort Study enables generational genetic discoveries.NATURE,626(7999),565-+. |
| MLA | Huang, Shujia,et al."The Born in Guangzhou Cohort Study enables generational genetic discoveries".NATURE 626.7999(2024):565-+. |
入库方式： OAI收割
来源：古脊椎动物与古人类研究所
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