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Sex difference in association between suicide attempts and lipid profile in first-episode and drug naive patients with major depressive disorder

文献类型：期刊论文

作者Guo, Junru1,2; Wang, Li1,3,4; Zhao, Xiaoqing5; Wang, Dongmei3,4,6; Zhang, Xiangyang3,4,6
刊名JOURNAL OF PSYCHIATRIC RESEARCH
出版日期2024-04-01
卷号172页码:24-33
关键词Sex differences Suicide attempt Lipid profile Major depressive disorder
ISSN号0022-3956
DOI10.1016/j.jpsychires.2024.02.026
通讯作者Wang, Dongmei(wangdm@psych.ac.cn) ; Zhang, Xiangyang(zhangxy@psych.ac.cn)
英文摘要Background: The relationship between suicide attempts and lipid profiles in patients with major depressive disorder (MDD) remains uncertain. The purpose of this study was to investigate sex differences in the relationship between suicide attempts and plasma lipid profiles in a large sample of first -episode and drug naive (FEDN) MDD patients. Methods: We recruited 1718 FEDN MDD patients and gathered demographic, clinical, and blood lipid data. The Hamilton Depression Rating Scale, Hamilton Anxiety Rating Scale and the Positive and Negative Syndrome Scale were used to assess the symptoms of patients. Results: There was no significant difference in the prevalence of suicide attempts between male and female MDD patients. The suicide attempt group had higher levels of depression, anxiety, psychotic symptoms, total cholesterol (TC), and low -density lipoprotein cholesterol (LDL-C), but lower levels of high -density lipoprotein cholesterol (HDL-C) levels than the non -suicide attempt group. Binary logistic regression showed that TC levels were significantly correlated with suicidal attempts in both male and female patients. Correlation analysis revealed that the levels of TC, HDL-C and LDL-C were significantly associated with the number of suicide attempts in both male and female patients. Further multiple linear regression revealed that TC levels were significantly associated with the number of suicide attempts in male patients only. Conclusions: Lipid biomarkers, particularly high TC levels, are associated with suicide attempts in both male and female MDD patients. However, there is gender difference in association between lipid biomarkers, especially TC levels, and the number of suicide attempts in MDD patients.
收录类别SCI
WOS关键词LOW SERUM-CHOLESTEROL ; DENSITY-LIPOPROTEIN CHOLESTEROL ; GENDER-DIFFERENCES ; RISK-FACTORS ; CIGARETTE-SMOKING ; PSYCHIATRIC-PATIENTS ; ANXIOUS DEPRESSION ; CHINA ; WOMEN ; BEHAVIOR
资助项目The 2023 Humanities and Social Sciences Research Base Program for Guizhou Colleges and Universities[23RWJD106] ; Institute of Psychology, CAS[GJ202006] ; Guizhou Minzu University[GJ202006] ; Social Science Foundation Project of Beijing[18GLB039]
WOS研究方向Psychiatry
语种英语
WOS记录号WOS:001185553900001
出版者PERGAMON-ELSEVIER SCIENCE LTD
资助机构The 2023 Humanities and Social Sciences Research Base Program for Guizhou Colleges and Universities ; Institute of Psychology, CAS ; Guizhou Minzu University ; Social Science Foundation Project of Beijing
源URL[http://ir.psych.ac.cn/handle/311026/47454]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Wang, Dongmei; Zhang, Xiangyang
作者单位1.Guizhou Normal Univ, Sch Psychol, Guiyang 550025, Peoples R China
2.Guizhou Minzu Univ, Dept Psychol, Guiyang 550025, Guizhou, Peoples R China
3.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
5.Guizhou Univ, Student Affairs Off, Guiyang 550025, Peoples R China
6.Chinese Acad Sci, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China
推荐引用方式
GB/T 7714		 Guo, Junru,Wang, Li,Zhao, Xiaoqing,et al. Sex difference in association between suicide attempts and lipid profile in first-episode and drug naive patients with major depressive disorder[J]. JOURNAL OF PSYCHIATRIC RESEARCH,2024,172:24-33.
APA Guo, Junru,Wang, Li,Zhao, Xiaoqing,Wang, Dongmei,&Zhang, Xiangyang.(2024).Sex difference in association between suicide attempts and lipid profile in first-episode and drug naive patients with major depressive disorder.JOURNAL OF PSYCHIATRIC RESEARCH,172,24-33.
MLA Guo, Junru,et al."Sex difference in association between suicide attempts and lipid profile in first-episode and drug naive patients with major depressive disorder".JOURNAL OF PSYCHIATRIC RESEARCH 172(2024):24-33.

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来源：心理研究所

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