Isolation, structural elucidation, and bioactivity of cholestane derivatives from Ypsilandra thibetica
文献类型:期刊论文
作者 | Xie, Jing; Zhang, Shi-Juan; Yue, Grace Gar-Lee; Yu, Ling-Ling; Liu, Hui; Ma, Wen-Yi; Yan, Huan; Ni, Wei; Lau, Clara Bik-San; Liu, Hai-Yang![]() |
刊名 | NEW JOURNAL OF CHEMISTRY
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出版日期 | 2022 |
卷号 | 47期号:1页码:324-332 |
关键词 | SPIROSTANE GLYCOSIDES STEROIDAL SAPONINS GROWTH |
DOI | 10.1039/d2nj04576a |
英文摘要 | Phytochemical investigation on the whole plant of Ypsilandra thibetica led to the isolation of five new cholestane derivatives. The structures of 1-5 were elucidated by comprehensive spectroscopic analyses of their data and chemical methods. The absolute configurations of compounds 1-3 were ambiguously assigned by single crystal X-ray diffraction analysis. Compound 1 is the first cholestane glycoside with two oxygen bridges between C-16/C-23 and C-18/C-23. Compound 2 is the first 23-spirocholestane derivative with a six-membered ring between C-24/C-23 of the aglycone moiety and C-1 & PRIME;/C-2 & PRIME; of the d-arabinose ligand, while compounds 3-5 are new 23-spirocholestane derivatives with a d-fucose ligand. The cytotoxic, anti-inflammatory, and anti-angiogenic activities of these isolated compounds were evaluated. Compound 5 showed anti-angiogenic activity in zebrafish embryos. |
WOS记录号 | WOS:000900709800001 |
源URL | [http://ir.kib.ac.cn/handle/151853/74662] ![]() |
专题 | 中国科学院昆明植物研究所 |
推荐引用方式 GB/T 7714 | Xie, Jing,Zhang, Shi-Juan,Yue, Grace Gar-Lee,et al. Isolation, structural elucidation, and bioactivity of cholestane derivatives from Ypsilandra thibetica[J]. NEW JOURNAL OF CHEMISTRY,2022,47(1):324-332. |
APA | Xie, Jing.,Zhang, Shi-Juan.,Yue, Grace Gar-Lee.,Yu, Ling-Ling.,Liu, Hui.,...&Liu, Hai-Yang.(2022).Isolation, structural elucidation, and bioactivity of cholestane derivatives from Ypsilandra thibetica.NEW JOURNAL OF CHEMISTRY,47(1),324-332. |
MLA | Xie, Jing,et al."Isolation, structural elucidation, and bioactivity of cholestane derivatives from Ypsilandra thibetica".NEW JOURNAL OF CHEMISTRY 47.1(2022):324-332. |
入库方式: OAI收割
来源:昆明植物研究所
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