Synthesis, Crystal Structures, and Cytotoxic Activity of Two Acetyl Chroman Derivatives
文献类型：期刊论文
| 作者 | Hu, X. X.; Huang, Z. F.; Lu, G. S.; Huang, J. Y.; Li, X. N.; Tan, X.; Feng, D. |
| 刊名 | RUSSIAN JOURNAL OF ORGANIC CHEMISTRY
 |
| 出版日期 | 2022 |
| 卷号 | 58期号:12页码:1861-1867 |
| 关键词 | acetyl chroman derivative X-ray analysis crystal structures cytotoxicity |
| DOI | 10.1134/S1070428022120156 |
| 英文摘要 | Two acetyl chroman derivative, 1-(5,7-dihydroxy-2,2-dimethylchroman-8-yl)ethan-1-one (1) and 1-(5,7-dihydroxy-2,2-dimethylchroman-6-yl)ethan-1-one (2) were synthesized as intermediate products in the preparation of flavonoids. Their structures were characterized by NMR and IR and confirmed by high-resolution mass spectra and single crystal X-ray analysis. The inhibitory effects of the synthesized compounds on the growth of A549, HepG2, SW480, and MCF-7 cancer cell lines were evaluated by the CCK8 methods. Compound 1 showed cytotoxicity against HepG2, SW480, and MCF-7 cell lines with IC50 values of 12.85, 23.94, and 28.72 mu M, respectively, and compound 2 showed cytotoxicity against HepG2 and MCF-7 cell lines with IC50 values of 24.78 and 23.87 mu M, respectively. |
| WOS记录号 | WOS:000933777000015 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/74671]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Hu, X. X.,Huang, Z. F.,Lu, G. S.,et al. Synthesis, Crystal Structures, and Cytotoxic Activity of Two Acetyl Chroman Derivatives[J]. RUSSIAN JOURNAL OF ORGANIC CHEMISTRY,2022,58(12):1861-1867. |
| APA | Hu, X. X..,Huang, Z. F..,Lu, G. S..,Huang, J. Y..,Li, X. N..,...&Feng, D..(2022).Synthesis, Crystal Structures, and Cytotoxic Activity of Two Acetyl Chroman Derivatives.RUSSIAN JOURNAL OF ORGANIC CHEMISTRY,58(12),1861-1867. |
| MLA | Hu, X. X.,et al."Synthesis, Crystal Structures, and Cytotoxic Activity of Two Acetyl Chroman Derivatives".RUSSIAN JOURNAL OF ORGANIC CHEMISTRY 58.12(2022):1861-1867. |
入库方式： OAI收割
来源：昆明植物研究所
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