Cytotoxic Picrotoxane-type Sesquiterpenoid Lactones from Dendrobium huoshanense
文献类型：期刊论文
| 作者 | Chen, Xiaoxiao; Hu, Jiaomiao; Wu, Siyu; Zhao, Hongsu; Peng, Daiyin; Wu, Deling; Xu, Fengqing |
| 刊名 | RECORDS OF NATURAL PRODUCTS
 |
| 出版日期 | 2022 |
| 卷号 | 16期号:2页码:144-149 |
| 关键词 | Dendrobium huoshanense picrotoxane-type sesquiterpene cytotoxicity CHEMICAL-CONSTITUENTS |
| DOI | 10.25135/rnp.260.21.04.2048 |
| 英文摘要 | Bioassay-guided led to the isolation of five compounds, including a new picrotoxane-type sesquiterpene lactone, aduncin C (1), together with four known ones (2-5) from Dendrobium huoshanense. Their structures were elucidated by means of extensive spectroscopic analysis. Biological evaluation of the isolates against four human cancer cell lines indicated broad-spectrum and cytotoxic activities with IC50 values ranging from 4.08 to 26.75 mu M. Among them, alpha-dihydropicrotoxinin (3) exhibited significant cell proliferation inhibitory activity, especially for HL-60 (IC50 5.81 mu M), MCF- 7 (IC50 6.49 mu M), SW-480 (IC50 6.80 mu M), respectively. |
| WOS记录号 | WOS:000690403000004 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/74717]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Chen, Xiaoxiao,Hu, Jiaomiao,Wu, Siyu,et al. Cytotoxic Picrotoxane-type Sesquiterpenoid Lactones from Dendrobium huoshanense[J]. RECORDS OF NATURAL PRODUCTS,2022,16(2):144-149. |
| APA | Chen, Xiaoxiao.,Hu, Jiaomiao.,Wu, Siyu.,Zhao, Hongsu.,Peng, Daiyin.,...&Xu, Fengqing.(2022).Cytotoxic Picrotoxane-type Sesquiterpenoid Lactones from Dendrobium huoshanense.RECORDS OF NATURAL PRODUCTS,16(2),144-149. |
| MLA | Chen, Xiaoxiao,et al."Cytotoxic Picrotoxane-type Sesquiterpenoid Lactones from Dendrobium huoshanense".RECORDS OF NATURAL PRODUCTS 16.2(2022):144-149. |
入库方式： OAI收割
来源：昆明植物研究所
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