The Extracts of Dendrobium Alleviate Dry Eye Disease in Rat Model by Regulating Aquaporin Expression and MAPKs/NF-kappa B Signalling
文献类型：期刊论文
| 作者 | Ling, Jiawei; Chan, Chung-Lap; Ho, Chi-Yan; Gao, Xun; Tsang, Sin-Man; Leung, Ping-Chung; Hu, Jiang-Miao ; Wong, Chun-Kwok
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| 刊名 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
 |
| 出版日期 | 2022 |
| 卷号 | 23期号:19页码:11195 |
| 关键词 | dry eye disease Dendrobium aquaporin scopolamine human cornea keratocytes TNF-ALPHA ACTIVATION CLASSIFICATION INFLAMMATION DEFINITION IL-1-BETA APOPTOSIS PATHWAYS STRESS MMP-9 |
| DOI | 10.3390/ijms231911195 |
| 英文摘要 | Dry eye is one of the most common ocular surface diseases caused by tear film instability and ocular surface damage due to an abnormal quality or quantity of tears. Inflammatory factors can initiate relevant transduction signalling pathways and trigger the inflammatory cascade response, resulting in ocular surface inflammation. It has been shown that the active ingredients in Dendrobium, such as polysaccharides, alkaloids and phenols, have anti-inflammatory, anti-tumour and immunity-boosting effects, and Dendrobium officinale extract can improve glandular secretion function, increase salivary secretion and increase the expression level of water channel protein in salivary glands in patients with dry eye syndromes. We investigated the in vitro cytoprotective effect of Dendrobium extracts in sodium chloride induced hyperosmotic conditions in human cornea keratocytes (HKs). Results showed that Dendrobium officinale Kimura et Migo water extract (DOW) and Dendrobium loddigesii Rolfe water extract (DLW) could upregulate the expression of aquaporins (AQP)5 protein, thus exerting a repairing effect by promoting cell migration. Furthermore, oral administration of DOW and DLW enhanced tear production in rats and exerted a protective effect on ocular surface damage. DOW and DLW could upregulate the expression of AQP5 and mucin (muc)5ac proteins in the lacrimal gland and reduce the inflammatory response. DOW and DLW inhibited the activation of the corresponding mitogen-activated protein kinases (MAPK) and NF-KB pathway, thereby playing a role in improving dry eye symptoms. This study provides a new perspective on dry eye treatment, and DOW and DLW may be potential therapeutic agents for dry eye. |
| WOS记录号 | WOS:000867779100001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/74723]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Ling, Jiawei,Chan, Chung-Lap,Ho, Chi-Yan,et al. The Extracts of Dendrobium Alleviate Dry Eye Disease in Rat Model by Regulating Aquaporin Expression and MAPKs/NF-kappa B Signalling[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2022,23(19):11195. |
| APA | Ling, Jiawei.,Chan, Chung-Lap.,Ho, Chi-Yan.,Gao, Xun.,Tsang, Sin-Man.,...&Wong, Chun-Kwok.(2022).The Extracts of Dendrobium Alleviate Dry Eye Disease in Rat Model by Regulating Aquaporin Expression and MAPKs/NF-kappa B Signalling.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,23(19),11195. |
| MLA | Ling, Jiawei,et al."The Extracts of Dendrobium Alleviate Dry Eye Disease in Rat Model by Regulating Aquaporin Expression and MAPKs/NF-kappa B Signalling".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 23.19(2022):11195. |
入库方式： OAI收割
来源：昆明植物研究所
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