A Small Natural Molecule S3 Protects Retinal Ganglion Cells and Promotes Parkin-Mediated Mitophagy against Excitotoxicity
文献类型：期刊论文
| 作者 | Zhuang, Dongli; Zhang, Rong; Liu, Haiyang ; Dai, Yi
|
| 刊名 | MOLECULES
 |
| 出版日期 | 2022 |
| 卷号 | 27期号:15页码:4957 |
| 关键词 | excitotoxicity retinal ganglion cells 15-oxospiramilactone mitophagy parkin MITOCHONDRIAL USP30 |
| DOI | 10.3390/molecules27154957 |
| 英文摘要 | Glutamate excitotoxicity may contribute to retinal ganglion cell (RGC) degeneration in glaucoma and other optic neuropathies, leading to irreversible blindness. Growing evidence has linked impaired mitochondrial quality control with RGCs degeneration, while parkin, an E3 ubiquitin ligase, has proved to be protective and promotes mitophagy in RGCs against excitotoxicity. The purpose of this study was to explore whether a small molecule S3 could modulate parkin-mediated mitophagy and has therapeutic potential for RGCs. The results showed that as an inhibitor of deubiquitinase USP30, S3 protected cultured RGCs and improved mitochondrial health against NMDA-induced excitotoxicity. Administration of S3 promoted the parkin expression and its downstream mitophagy-related proteins in RGCs. An upregulated ubiquitination level of Mfn2 and protein level of OPA1 were also observed in S3-treated RGCs, while parkin knockdown resulted in a major loss of the protective effect of S3 on RGCs under excitotoxicity. These findings demonstrated that S3 promoted RGC survival mainly through enhancing parkin-mediated mitophagy against excitotoxicity. The neuroprotective value of S3 in glaucoma and other optic neuropathies deserves further investigation. |
| WOS记录号 | WOS:000839828500001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/74738]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Zhuang, Dongli,Zhang, Rong,Liu, Haiyang,et al. A Small Natural Molecule S3 Protects Retinal Ganglion Cells and Promotes Parkin-Mediated Mitophagy against Excitotoxicity[J]. MOLECULES,2022,27(15):4957. |
| APA | Zhuang, Dongli,Zhang, Rong,Liu, Haiyang,&Dai, Yi.(2022).A Small Natural Molecule S3 Protects Retinal Ganglion Cells and Promotes Parkin-Mediated Mitophagy against Excitotoxicity.MOLECULES,27(15),4957. |
| MLA | Zhuang, Dongli,et al."A Small Natural Molecule S3 Protects Retinal Ganglion Cells and Promotes Parkin-Mediated Mitophagy against Excitotoxicity".MOLECULES 27.15(2022):4957. |
入库方式： OAI收割
来源：昆明植物研究所
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