Branched Chondroitin Sulfate Oligosaccharides Derived from the Sea Cucumber Acaudina molpadioides Stimulate Neurite Outgrowth
文献类型：期刊论文
| 作者 | Wang, Weili; Mao, Hui; Li, Sujuan; Zhang, Longlong; Yang, Lian; Yin, Ronghua; Zhao, Jinhua
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| 刊名 | MARINE DRUGS
 |
| 出版日期 | 2022 |
| 卷号 | 20期号:10页码:653 |
| 关键词 | fucosylated chondroitin sulfate sea cucumber disaccharide branch oligosaccharide neurite outgrowth stimulation HIPPOCAMPAL-NEURONS PROMOTING ACTIVITY GLYCOSAMINOGLYCAN DISACCHARIDE INHIBITOR |
| DOI | 10.3390/md20100653 |
| 英文摘要 | Fucosylated chondroitin sulfate (FCS) from the sea cucumber Acaudina molpadioides (FCSAm) is the first one that was reported to be branched by disaccharide GalNAc-(alpha 1,2)-Fuc(3S4S) (15%) and sulfated Fuc (85%). Here, four size-homogenous fractions, and seven oligosaccharides, were separated from its beta-eliminative depolymerized products. Detailed NMR spectroscopic and MS analyses revealed the oligomers as hexa-, hepta-, octa-, and nonasaccharide, which further confirmed the precise structure of native FCSAm: it was composed of the CS-E-like backbone with a full content of sulfation at O-4 and O-6 of GalNAc in the disaccharide repeating unit, and the branches consisting of sulfated fucose (Fuc(4S) and Fuc(2S4S)) and heterodisaccharide [GalNAc-(alpha 1,2)-Fuc(3S4S)]. Pharmacologically, FCSAm and its depolymerized derivatives, including fractions and oligosaccharides, showed potent neurite outgrowth-promoting activity in a chain length-dependent manner. A comparison of analyses among oligosaccharides revealed that the sulfate pattern of the Fuc branches, instead of the heterodisaccharide, could affect the promotion intensity. Fuc(2S4S) and the saccharide length endowed the neurite outgrowth stimulation activity most. |
| WOS记录号 | WOS:000873081700001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/74740]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Wang, Weili,Mao, Hui,Li, Sujuan,et al. Branched Chondroitin Sulfate Oligosaccharides Derived from the Sea Cucumber Acaudina molpadioides Stimulate Neurite Outgrowth[J]. MARINE DRUGS,2022,20(10):653. |
| APA | Wang, Weili.,Mao, Hui.,Li, Sujuan.,Zhang, Longlong.,Yang, Lian.,...&Zhao, Jinhua.(2022).Branched Chondroitin Sulfate Oligosaccharides Derived from the Sea Cucumber Acaudina molpadioides Stimulate Neurite Outgrowth.MARINE DRUGS,20(10),653. |
| MLA | Wang, Weili,et al."Branched Chondroitin Sulfate Oligosaccharides Derived from the Sea Cucumber Acaudina molpadioides Stimulate Neurite Outgrowth".MARINE DRUGS 20.10(2022):653. |
入库方式： OAI收割
来源：昆明植物研究所
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