Yi Shen An, a Chinese traditional prescription, ameliorates membranous glomerulonephritis induced by cationic bovine serum albumin in rats
文献类型：期刊论文
| 作者 | Zhao, Yun-Li; Zhang, Xiang-Hua; Guo, Feng; Wei, Ying; Shang, Jian-Hua; Luo, Xiao-Dong
|
| 刊名 | PHARMACEUTICAL BIOLOGY
 |
| 出版日期 | 2022 |
| 卷号 | 60期号:1页码:163-174 |
| 关键词 | Nephritis circulating immune complex proteinuria podocytes OXIDATIVE STRESS DIABETIC-NEPHROPATHY NEPHROTIC SYNDROME GLOMERULAR INJURY PATHOGENESIS COMPLEMENT INFLAMMATION PROGRESSION NEPHRITIS CELLS |
| DOI | 10.1080/13880209.2021.2021947 |
| 英文摘要 | Context Yi Shen An (YSA) is an investigational composite of traditional Chinese medicine (Reference: 2010L000974) for the treatment of renal disease. Objective To investigate the protective effects of YSA against membranous glomerulonephritis (MGN). Materials and methods Male Sprague-Dawley rats were injected with cationic bovine serum albumin (C-BSA) to create a model of MGN. Then, rats were orally treated with YSA at doses of 0.25, 0.5, 1 and 2 g/kg for 35 successive days; prednisone (5 mg/kg) was used as a positive control. At the end of the experimental period, we performed a series of tests, including 24 h urinary protein, and biochemical, immunological, antioxidative, coagulation indices, and histopathological examination. Results YSA-1 g/kg significantly lowered urinary protein from 68.37 to 30.74 mg (p < 0.01). Meantime, total protein (TP) and albumin (ALB) recovered from 66.26 and 20.51 g/L to 76.08 and 35.64 g/L (p < 0.01), respectively. YSA removed the deposition of immunoglobulin G (IgG) and complement 3c (C3c), prevented inter-capillary cell hyperplasia on the glomerular basement membrane (GBM), and reduced electron-dense deposits and fusion of podocytes. In addition, serum IgG and superoxide dismutase were significantly elevated. In contrast, malondialdehyde, total cholesterol, triglyceride, circulating immune complex (CIC), and immunoglobulin M decreased in the YSA-treated group. Moreover, the blood coagulation dysfunction was adjusted. Discussion and conclusions These findings indicate YSA may exert a therapeutic effect against MGN through the inhibition of CIC formation, and the removal of IgG and C3c deposition from the GBM, thus supporting the development of further clinical trials. |
| WOS记录号 | WOS:000740524000001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/74762]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Zhao, Yun-Li,Zhang, Xiang-Hua,Guo, Feng,et al. Yi Shen An, a Chinese traditional prescription, ameliorates membranous glomerulonephritis induced by cationic bovine serum albumin in rats[J]. PHARMACEUTICAL BIOLOGY,2022,60(1):163-174. |
| APA | Zhao, Yun-Li,Zhang, Xiang-Hua,Guo, Feng,Wei, Ying,Shang, Jian-Hua,&Luo, Xiao-Dong.(2022).Yi Shen An, a Chinese traditional prescription, ameliorates membranous glomerulonephritis induced by cationic bovine serum albumin in rats.PHARMACEUTICAL BIOLOGY,60(1),163-174. |
| MLA | Zhao, Yun-Li,et al."Yi Shen An, a Chinese traditional prescription, ameliorates membranous glomerulonephritis induced by cationic bovine serum albumin in rats".PHARMACEUTICAL BIOLOGY 60.1(2022):163-174. |
入库方式： OAI收割
来源：昆明植物研究所
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